Holding(s) in Company

Tate & Lyle PLC

TR-1: Notifications of Major Interests in Shares

1. Identity of the issuer or the underlying issuer of existing shares to which voting rights are attached:

TATE & LYLE PLC

2. Reason for notification (yes/no)

An acquisition or disposal of voting rights

An acquisition or disposal of financial instruments which may result in the acquisition of shares already issued to which voting rights are attached

An acquisition or disposal of instruments with similar economic effect to qualifying financial instruments

An event changing the breakdown of voting rights

Other (please specify):______________

3. Full name of person(s) subject to notification obligation:

TIAA-CREF Investment Management, LLC on behalf of the accounts listed in Exhibit B attached hereto

Teachers Advisors, Inc. on behalf of the funds listed in Exhibit C attached hereto

4. Full name of shareholder(s) (if different from 3):

See Number 3

5. Date of transaction (and date on which the threshold is crossed or reached if different):

05 October 2012

6. Date on which issuer notified:

08 October 2012

7. Threshold(s) that is/are crossed or reached:

8: Notified Details

A: Voting rights attached to shares

Class/type of shares

If possible use ISIN code

Situation previous to the triggering transaction

Resulting situation after the triggering transaction

Number of shares

Number of voting rights

Number of shares

Direct

Number of voting rights

Percentage of voting rights

Direct

Indirect

Direct

Indirect

GB0008754136

18,349,408

18,849,408

4.044%

B: Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Expiration date

Exercise/ conversion period

No. of voting rights that may be acquired (if the instrument exercised/converted)

Percentage of voting rights

N/A

C: Financial Instruments with similar economic effect to Qualifying Financial Instruments

Resulting situation after the triggering transaction

Type of financial instrument

Exercise price

Expiration date

Exercise/ conversion period

No. of voting rights instrument refers to

Percentage of voting rights

Nominal

Delta

N/A

Total (A+B+C)

Number of voting rights

Percentage of voting rights

18,849,408

4.044%

9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively held, if applicable:

The College Retirement Equities Fund (â€œCREFâ€) hereby informs you that on October 5, 2012, CREF bought 119,556 shares of Tate & Lyle PLC, bringing its total holdings in your company to 5,522,175 shares. CREF owns these shares through three of its investment accounts, the Global Equities Account, Stock Account and Social Choice Account. It is our understanding the total voting shares outstanding of Tate & Lyle Plc is 466,130,026 bringing CREFâ€™s ownership in your company to a 1.185% level.

For your information, CREF is a U.S. based investment company, which is registered with the Securities and Exchange Commission (â€œSECâ€). CREF has multiple investment accounts, each with separate investment objectives and policies. All assets in the accounts are beneficially owned by CREF, and all the accounts are managed by TIAA-CREF Investment Management, LLC, an SEC registered investment adviser.

Additionally, affiliates of CREF own 13,327,233 shares of Tate & Lyle PLC. These holdings are owned by the TIAA-CREF Funds (â€œFundsâ€) and TIAA-CREF Life Funds (â€œLife Fundsâ€) each of which are SEC registered investment companies, as well as one of the TIAA-CREF Active Extension Funds (â€œActive Extension Unregistered Fundsâ€). The Funds, Life Funds and Active Extension Unregistered Funds are managed by Teachers Advisors, Inc., an SEC registered investment adviser that is affiliated with TIAA-CREF Investment Management, LLC. These affiliated funds, aggregated with those of CREF, own a total of 18,849,408 shares or 4.044% of the outstanding voting shares of your company. Because Teachers Advisors, Inc. and TIAA-CREF Investment Management, LLC follow the same policies when voting these funds, we are aggregating the holdings for purposes of this letter.

(See Exhibit A attached hereto)

Proxy Voting:

10. Name of proxy holder:

TIAA-CREF Investment Management, LLC/ Teachers Advisors, Inc.

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

None

14. Contact name:

Stuart R. Brunet

15. Contact telephone number:

+1 415 882 3711

Listed Company Contact name:

Lucie Gilbert

Company Secretary

020 7257 2100

Exhibit A.

TIAA-CREF

Summary of Holdings of Tate & Lyle PLC

Between October 4, 2012 - October 5, 2012

	Â	TIAA-CREF Investment Management LLC ("CREF")
		Global Equities Account	Â	Stock Account	Â	Social Choice Account	Â	Total CREF Holdings	Â	Total CREF %
Holdings as of October 4, 2012		22,587		5,367,486		12,546		5,402,619		1.159%
		Â		Â		Â		Â		Â
Transactions as of October 5, 2012		-		119,556		-		119,556		0.026%
		Â		Â		Â		Â		Â
Holdings as of October 5, 2012		22,587		5,487,042		12,546		5,522,175		1.185%

Teachers Advisors, Inc.

TIAA-CREF International Equity Fund

TIAA-CREF Life International Equity Fund

TIAA-CREF Intl Equity Index Fund

TIAA-CREF ENH Intl Equity Index Fund

Active Extension Fund I

Total Mutual Funds Holdings

Total Mutual Funds %

Holdings as of October 4, 2012

12,297,341

320,333

154,553

155,926

18,636

12,946,789

2.778%

Transactions as of October 5, 2012

370,628

9,816

380,444

0.082%

Holdings as of October 5, 2012

12,667,969

330,149

154,553

155,926

18,636

13,327,233

2.859%

	Â	Aggregate Holding
		Total Holdings	Â	Total %
Holdings as of October 4, 2012		18,349,408		3.937%
		Â		Â
Transactions as of October 5, 2012		500,000		0.107%
		Â		Â
Holdings as of October 5, 2012		18,849,408		4.044%