Annual Information Update

25 March 2009

                         Microgen plc (the "Company")                          

                           Annual Information Update                           

In accordance with Prospectus Rule 5.2, the Company sets out below its Annual
Information Update relating to information which has been published or made
available to the public up to and including 25 March 2009.

1. Regulatory Announcements

The following UK regulatory announcements have been issued through PRN or RNS,
both Regulatory Information Services. They can be viewed or downloaded from the
London Stock Exchange Web Site (www.londonstockexchange.com) in the Market News
section, searching under the Company's code MCGN.

Date      Regulatory Headline and Detail

26-Feb-09 Director Shareholding

25-Feb-09 Director Shareholding

24-Feb-09 Final Results

20-Feb-09 Notice of Results

17-Feb-09 Holding(s) in Company

27-Jan-09 Holding(s) in Company

22-Jan-09 Blocklisting - Interim Review

22-Jan-09 Holding(s) in Company

16-Jan-09 Blocklisting - Interim Review

17-Dec-08 Holding(s) in Company

03-Dec-08 Holding(s) in Company

02-Dec-08 Director/PDMR Shareholding

02-Dec-08 Director/PDMR Shareholding

02-Dec-08 Holding(s) in Company

27-Nov-08 Holding(s) in Company

27-Nov-08 Total Voting Rights

21-Nov-08 Result of Tender Offer

19-Nov-08 Result of General Meeting

13-Nov-08 Correction to Shareholder Circular

06-Nov-08 Holding(s) in Company

31-Oct-08 Posting of Shareholder Circular

14-Oct-08 Interim Management Statement

07-Oct-08 Company Secretary Change

04-Aug-08 Total Voting Rights

17-Jul-08 Interim Results

15-Jul-08 Notice of Results

02-Jul-08 Blocklisting - Interim Review

24-Jun-08 Additional Listing

27-May-08 Holding(s) in Company

27-May-08 Total Voting Rights

06-May-08 Annual Information Update

2. Documents filed at Companies House

The Company filed the following documents at Companies House on or around the
dates indicated.

Date Document Type

12-Dec-08 169 Return by Company purchasing own shares

24-Nov-08 RES09 Ordinary Resolution relating to Bonus Scheme

09-Oct-08 288b Company Secretary resigned

09-Oct-08 288a Company Secretary appointed

30-Sep-08 MEM/ARTS Memorandum of Association / Articles of Association

11-Aug-08 88 (2) Return of Allotment of Shares

17-Jun-08 Annual Accounts For the year ended 31 December 2007

16-May-08 88 (2) Return of Allotment of Shares

15-May-08 363s Annual Return made up to 12 April 2008

Copies of the documents filed at Companies House can be obtained from Companies
House website at www.companieshouse.gov.uk or Companies House, Crown Way,
Cardiff, CF14 3UZ.

 3. Documents sent to Shareholders
   
The following documents have been published by the Company and sent to the
Company's shareholders and were submitted to the UK Listing Authority's Viewing
Facility on the dates listed below.

Date              Document                                              
                                                                        
13 March 2009     Annual Report and Accounts 2008                       
                                                                        
                  Notice of Annual General Meeting 2009                 
                                                                        
                  Proxy Card for Annual General Meeting 2009            
                                                                        
31 October 2008   Proposed return of up to £8m to Shareholders by way of
                  Tender Offer, Proposed Microgen Value Enhancement &   
                  Realisation Bonus Scheme and Notice of General Meeting
                                                                        
                  Proxy Card for General Meeting                        
                                                                        
1 August 2008     Interim Report for the six months to 30 June 2008     

A copy of this Annual Information Update and all documents referred to in it
can be obtained from the Group's registered office:

Microgen plc
Fleet House
3 Fleetwood Park
Barley Way
Fleet
Hampshire
GU51 2QJ

This Annual Information Update is required by, and is being made pursuant to,
Article 10 of the Prospectus Directive as implemented in the UK by Prospectus
Rule 5.2 and not for any other purpose. Information is referred to in this
update rather than included in full. The information referred to was up to date
at the time it was published; however, some information may now be out of date.
Neither the Company, nor any other person, takes any responsibility for, or
makes any representation (express or implied) as to the accuracy or
completeness of the information.

For further information, please contact:

A. Siddiqi, Company Secretary 01252 772 326