Director Shareholding

5 December 2007

Microgen plc (the "Company")

Notification of Interests of Directors and Connected Persons

In accordance with DR 3.1.4R (1) (a) and (b) the Company announces that on 4
December 2007 its Chairman, Martyn Ratcliffe, acquired 210,000 Ordinary Shares
in the Company representing 0.20% of the issued class, at the following price:

100,000 at 40 pence

85,000 at 40.75 pence

25,000 at 42 pence

Following this transaction, Mr Ratcliffe's total beneficial shareholding is
5,019,524 shares, representing 4.88% of the issued class.

If you require further information please contact:

G.E. Liddle, Company Secretary

Tel: [phone]

www.microgen.co.uk