Annual Information Update

5 August 2009 THE BIOTECH GROWTH TRUST PLC (the "Company") ANNUAL INFORMATION UPDATE For the 12 months ending Wednesday, 31 July 2009 In accordance with the Prospectus Rule 5.2, the Company reports upon information that it has published or made available to the public over the 12 months ending on 31 July 2009. In accordance with PR5.2.7 some of the announcements during the year may relate to matters which have subsequently changed since the original announcement. Company Announcements With the exception of the daily net asset value announcements, the Company has made the following announcements through PR Newswire (PRN): Date of Publication Summary Description Method of Publication 30 July 2009 Annual Financial Report PRN 24 July 2009 Director/PDMR Shareholding PRN 24 July 2009 Director/PDMR Shareholding PRN 24 July 2009 Director/PDMR Shareholding PRN 24 July 2009 Director/PDMR Shareholding PRN 23 July 2009 AGM Statement PRN 3 July 2009 Transaction in own shares PRN 1 July 2009 Total Voting Rights PRN 22 June 2009 Annual Financial Report PRN 8 June 2009 Final Results PRN 1 June 2009 Total Voting Rights PRN 15 May 2009 Transaction in own shares PRN 11 May 2009 Transaction in own shares PRN 1 May 2009 Total Voting Rights PRN 17 April 2009 Transaction in own shares PRN 3 April 2009 Transaction in own shares PRN 1 April 2009 Total Voting Rights PRN 1 April 2009 Compliance with Model Code PRN 27 March 2009 Transaction in own shares PRN 23 March 2009 Holding in Company PRN 20 March 2009 Transaction in own shares PRN 18 March 2009 Holding in Company PRN 6 March 2009 Transaction in own shares PRN 2 March 2009 Total Voting Rights PRN 20 February 2009 Transaction in own shares PRN 16 February 2009 Holding in Company PRN 16 February 2009 Interim Management Statement PRN 13 February 2009 Transaction in own shares PRN 6 February 2009 Transaction in Own Shares PRN 2 February 2009 Total Voting Rights PRN 30 January 2009 Transaction in Own Shares PRN 16 January 2009 Transaction in Own Shares PRN 9 January 2009 Transaction in Own Shares PRN 5 January 2009 Total Voting Rights PRN 31 December 2008 Transaction in Own Shares PRN 24 December 2008 Transaction in Own Shares PRN 19 December 2008 Transaction in Own Shares PRN 12 December 2008 Transaction in Own Shares PRN 5 December 2008 Transaction in Own Shares PRN 1 December 2008 Total Voting Rights PRN 28 November 2008 Half-yearly Report PRN 28 November 2008 Transaction in Own Shares PRN 21 November 2008 Transaction in Own Shares PRN 14 November 2008 Transaction in Own Shares PRN 7 November 2008 Transaction in Own Shares PRN 4 November 2008 Total Voting Rights PRN 31 October 2008 Transaction in Own Shares PRN 24 October 2008 Transaction in Own Shares PRN 17 October 2008 Transaction in Own Shares PRN 9 October 2008 Transaction in Own Shares PRN 3 October 2008 Transaction in Own Shares PRN 3 October 2008 Holding in Company PRN 1 October 2008 Compliance with Model Code PRN 1 October 2008 Total Voting Rights PRN 26 September 2008 Transaction in Own Shares PRN 19 September 2008 Transaction in Own Shares PRN 12 September 2008 Transaction in Own Shares PRN 5 September 2008 Transaction in Own Shares PRN 1 September 2008 Total Voting Rights PRN 22 August 2008 Transaction in Own Shares PRN 15 August 2008 Transaction in Own Shares PRN 6 August 2008 Interim Management Statement PRN 1 August 2008 Total Voting Rights PRN Filings at Companies House During the year the following documents were filed at Companies House: Date Document Number Description 11 July 2008 G169 Transaction in own shares 8 July 2008 G169 Transaction in own shares 26 June 2008 G169 Transaction in own shares 15 May 2009 G169 Transaction in own shares 8 May 2009 G169 Transaction in own shares 24 June 2009 Annual Accounts Annual Report & Accounts 17 April 2009 G169 Transaction in own shares 3 April 2009 G169 Transaction in own shares 27 July 2009 - Resolutions passed at the AGM 17 June 2009 363s Annual Return 27 March 2009 G169 Transaction in own shares 20 March 2009 G169 Transaction in own shares 6 March 2009 G169 Transaction in own shares 20 February 2009 G169 Transaction in own shares 13 February 2009 G169 Transaction in own shares 6 February 2009 G169 Transaction in own shares 30 January 2009 G169 Transaction in own shares 16 January 2009 G169 Transaction in own shares 9 January 2009 G169 Transaction in own shares 31 December 2008 G169 Transaction in own shares 24 December 2008 G169 Transaction in own shares 19 December 2008 G169 Transaction in own shares 12 December 2008 G169 Transaction in own shares 5 December 2008 G169 Transaction in own shares 28 November 2008 G169 Transaction in own shares 21 November 2008 G169 Transaction in own shares 14 November 2008 G169 Transaction in own shares 7 November 2008 G169 Transaction in own shares 31 October 2008 G169 Transaction in own shares 24 October 2008 G169 Transaction in own shares 17 October 2008 G169 Transaction in own shares 9 October 2008 G169 Transaction in own shares 3 October 2008 G169 Transaction in own shares 26 September 2008 G169 Transaction in own shares 19 September 2008 G169 Transaction in own shares 12 September 2008 G169 Transaction in own shares 5 September 2008 G169 Transaction in own shares 22 August 2008 G169 Transaction in own shares 15 August 2008 G169 Transaction in own shares 31 July 2008 G169 Transaction in own shares The following documents were filed with the UK Listing Authority Document Viewing Facility on or around the dates indicated. Date Document 15 June 2009 Annual Report & Accounts 27 November 2008 Interim Report & Accounts Special Resolutions passed at the AGM on 23 July 31 July 2009 2009 Inspection of Documents The Company publishes the following documents on its website at www.biotechgt.com Annual Report Interim Report Interim Management Statement Monthly Fact Sheets Copies of the documents that are required to be lodged at the FSA in accordance with the Listing Rules, Prospectus Rules and Disclosure Rules are available for inspection at the following address: Financial Services Authority 25 The North Colonnade Canary Wharf London E14 5HS Tel: 020 7676 1000 Copies of documents filed at Companies House are available from: Registrar of Companies Companies House Crown Way Cardiff CF14 3UZ Tel: 0870 3333 636 They may also be downloaded from the website at www.directcompanieshouse.gov.uk Further information may be obtained from: Mark Pope Frostrow Capital 25 Southampton Buildings London WC2A 1AL Company Secretary Tel. 020 3008 4913 Fax. 020 3043 8889

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