Half-yearly Report

The Biotech Growth Trust PLC Interim Report for the six months to 30 September 2007 Company Summary Performance Statistics 30 September 31 March % Change 2007 2007 Shareholders' Funds £75.6m £76.8m -1.6 Net asset value per share 117.0p 117.1p -0.1 Share price 111.8p 109.8p +1.8 Discount of share price to net asset value 4.4% 6.2% - per share NASDAQ Biotechnology Index (sterling 418.7 394.7 +6.1 adjusted) Investment Objective and Policy The Biotech Growth Trust PLC seeks capital appreciation through investment in the worldwide biotechnology industry, principally by investing in emerging biotechnology companies. Performance is measured against the NASDAQ Biotechnology Index (sterling adjusted). It is the Company's policy to invest no more that 15% of its gross assets in other listed investment companies (including listed investment trusts). Other that its investment in the Merlin Fund LP, which it has held since inception, the Company has never had a holding in an investment company of any sort, and the Directors do not currently envisage any circumstances in which it is likely to do so in the future. A significant proportion of the Company's assets are, and will continue to be, invested in securities denominated in foreign currencies, in particular U.S. dollars. As the Company's shares are denominated and trade in sterling, the return to shareholders will be affected by changes in the value of sterling relative to those foreign currencies. The Board has made clear the Company's position with regard to currency fluctuations which is that it does not currently hedge against currency exposure. Interim Dividend The Company has not declared an interim dividend (2006: nil). Capital Structure During the half year, a total of 978,000 shares were repurchased by the Company for cancellation. At 30 September 2007, the Company had 64,599,263 shares in issue. Since the end of the half year a further 255,500 shares have been repurchased for cancellation. As at 21 November 2007 the Company had 64,343,763 shares in issue. Continuation Vote The next continuation vote of the Company shall be held at the Annual General Meeting in 2010, further opportunities to vote on the continuation of the Company shall be given to shareholders every five years thereafter. Chairman's Statement Performance The period under review has again been a difficult one for stock markets as a whole and the Company's net asset value per share fell slightly by 0.1%. This compares to a rise in the Company's benchmark, NASDAQ Biotechnology Index measured in sterling terms, of 6.1%. Over the longer term however, since the appointment of OrbiMed Capital LLC as investment manager to the Company in May 2005, the net asset value per share has risen by 17.5% which compares to a rise in the benchmark index of 12.3%. The Company's share price rose over the period by 1.8% as the discount of share price to net asset value per share narrowed from 6.2% to 4.4%. It is disappointing to report a period when your Company's net asset value per share has again not made ground in absolute terms and in addition has underperformed the benchmark index. There are two principal reasons for this. First, the U.S. dollar again played its part in constraining the Company's absolute performance. It fell during the half year from $1.96 to £1 at the end of March 2007 to $2.04 to £1 at the end of September 2007, a drop of 4.1%. And second, relative to the index, the investment portfolio was weighted more towards smaller capitalisation biotechnology stocks which had a weak period relative to larger capitalisation stocks. This was largely because of a lack of merger and acquisition (`M&A') activity and some disappointing sales growth generally within the sector. The level of M&A activity within the biotech sector has picked up since the end of the period, most notably the board of Biogen Idec announcing that the company is for sale. We believe that we are well placed to benefit from further M&A activity in the future. Further details of the performance of the Investment Portfolio are set out within the Investment Manager's Review which forms part of the Company's Interim Report. Share Capital During the six months under review the Company repurchased a total of 978,000 shares at a cost of £1,062,000. All of these shares were cancelled. As at 30 September 2007 the Company held no shares in treasury. The Company remains committed to active discount management and to buying back shares if the market price is at a discount to net asset value per share of greater than 6%. Revenue and Dividends The revenue loss for the period was £126,000 (six months ended 30 September 2006: loss of £164,000) and no interim dividend is declared (six months ended 30 September 2006: nil). Composition of the Board Anthony Townsend retired from the Board on 8 November 2007. On behalf of all my colleagues I would particularly like to thank Anthony for his contribution to the Company over the whole of its life to date. Anthony, more than anyone else, should be regarded as the founder of the Company. We will greatly miss his attention to our affairs, his good advice and his great knowledge of the investment trust market. We wish him well with his future plans. Outlook Your Board remains of the view that the longer term outlook for the biotechnology sector is promising, with merger and acquisition activity being the key driver of performance for the sector as a whole. Notwithstanding shorter term challenges, your Board believes that the long term investor will be well rewarded. John Sclater CVO Chairman Interim Management Report Risks and Uncertainties A review of the half year and the outlook for the Company can be found in the Chairman's Statement and in the Review of Investments. The major risks associated with the Company are market price risk, gearing risk, liquidity risk, interest rate risk and currency movement risk. The Company has established a framework for managing these risks which is evolving continually in line with the Investment Manager's strategy. The Board has provided the Investment Manager with guidelines and limits for the management of market risk, gearing and financial assets and liabilities. The Company does not hedge its foreign currency exposure. Other key risks identified by the Board that could affect the Company's performance are as follows: * Performance risk: The performance of the Investment Portfolio relative to the benchmark (NASDAQ Biotechnology Index - measured in sterling terms) is monitored closely by the Board * Discount volatility: The Company's share price can trade at a discount to the underlying net asset value per share. The Company operates a discount protection policy and associated share buyback programme. * Regulatory risk: The Company operates in a complicated regulatory environment and faces a number of regulatory risks. Breaches of regulations, such as Section 842 of the Income and Corporation Taxes Act 1988, the UKLA Listing Rules and the Companies Act, could lead to a number of serious outcomes and reputational damage. The Audit Committee monitors compliance with regulations by reviewing internal control reports from the Manager and Investment Manager. Directors' Responsibilities The Directors are responsible for preparing the interim report in accordance with applicable law and regulations. The Directors confirm that to the best of their knowledge the interim financial statements, within the interim report, have been prepared in accordance with the Accounting Standards Board's Statement `Half Yearly Financial Reports' and that the Chairman's Statement and the Interim Management Report include a fair review if the information required by 4.2.7R and 4.2.8R of the FSA's Disclosure and Transparency Rules. The interim report has not been reviewed by the Company's auditors. The interim report was approved by the Board on 22 November 2007and the above responsibility statement was signed on its behalf by: John Sclater CVO Chairman Review Of Investments Performance In the six months ending 30 September 2007, the Company's net asset value per share underperformed its benchmark by approximately 6.2%. In absolute terms it declined 0.1% versus a 6.1% increase in the NASDAQ Biotechnology Index (sterling adjusted). Several factors contributed to our underperformance. We were underweight several major biotechnology positions that performed well during the term including Celgene and Gilead Sciences, both of which are large components of our benchmark. Additionally, the Company was invested in two companies which experienced clinical setbacks: Panacos Pharmaceuticals and Vion Pharmaceuticals. Environment and Outlook We continue to view merger and acquisition activity as a key strategic investment theme for positioning the Company. Recently the board of Biogen Idec publicly announced that it would consider a sale of the company. If completed, this would represent the fourth acquisition of a major biotechnology company in the last two years following the acquisitions of MedImmune, Serono and Chiron. Among emerging biotechnology companies, Aspreva received a $915 million acquisition offer from Galenica in October. The Company remains well positioned to benefit from anticipated merger & acquisition activity in the future. Larger capitalisation pharmaceutical stocks and large biotechnology stocks have also sought to gain rights to potential new products through the signing of partnerships. The value of late stage clinical programmes has climbed dramatically over the last several years as companies compete for these prized assets. In July, Ariad Pharmaceuticals partnered its lead drug for cancer with Merck in return for over $700 million in upfront fees, potential milestone payments and royalties. The upcoming U.S. Presidential election could create headline risk as investors weigh the impact of potential changes to the health care system, most importantly any pressure on drug pricing. We believe that biotechnology companies will be less impacted than large pharmaceutical firms because few biotechnology drugs face significant competition and biotechnology products are generally deemed to be more innovative and therefore worthy of a premium price. Prescription Drug User Free Act IV was an important piece of legislation passed by the U.S. Congress in September. This renewed an important programme which allows pharmaceutical manufacturers to pay fees to the U.S. Food and Drug Agency (FDA) in exchange for more timely regulatory decisions. Importantly, industry unfriendly provisions, such as regulations allowing follow-on biologics and the creation of a separate independent safety division at the FDA, were considered but left out of the final legislation. From a geographic perspective, our emphasis remains on North American biotechnology companies, which account for approximately 88% of assets. We have also identified several promising opportunities in Europe, which account for approximately 10% of assets. The unquoted positions now represent just 2.2% of assets. OrbiMed Capital LLC Investment Manager Income Statement For the six months ended 30 September 2007 (Unaudited) (Unaudited) (Audited) Six months ended Six months ended Year ended 30 September 2007 30 September 2006 31 March 2007 Revenue Capital Total Revenue Capital Total Revenue Capital Total £'000 £'000 £'000 £'000 £'000 £'000 £'000 £'000 £'000 Investment i ncome Investment 38 - 38 18 - 18 36 - 36 income Other income 6 - 6 2 - 2 8 - 8 Total income 44 - 44 20 - 20 44 - 44 (note 2) Gains and losses on investments (Losses)/ - (472) (472) - (2,947) (2,947) - 3,373 3,373 gains on investments held at fair value through profit or loss Exchange - (111) (111) - (104) (104) - (277) (277) losses on currency balances Expenses Investment - 575 575 - (463) (463) - (2,048) (2,048) management, management and performance fees (note 3) Other (155) - (155) (178) - (178) (355) - (355) expenses (Loss)/profit (111) (8) (119) (158) (3,514) (3,672) (311) 1,048 737 before finance costs and taxation Finance costs (15) (7) (22) (6) - (6) (20) (17) (37) (Loss)/profit (126) (15) (141) (164) (3,514) (3,678) (331) 1,031 700 before taxation Taxation - - - - - - - - - (Loss)/profit (126) (15) (141) (164) (3,514) (3,678) (331) 1,031 700 for the period (Loss)/ea (0.2)p (0.0)p (0.2)p (0.3)p (6.6)p (6.9)p (0.5)p 1.7p 1.2p rnings per share (note 4 ) The total column of this statement represents the Income Statement, prepared in accordance with IFRS. The revenue return and capital return columns are supplementary to this and are prepared under guidance published by the Association of Investment Companies. All items in the above statement derive from continuing operations. All income is attributable to the equity holders of The Biotech Growth Trust PLC. Statement of Changes in Equity For the six months ended 30 September 2007 Unaudited Six months ended 30 September 2007 Share Share Special Capital Capital Revenue Total £ Capital Premium Reserve Redemption Reserve Reserve '000 Account £'000 Reserve £'000 £'000 £'000 £'000 £'000 At 31 March 2007 16,394 - 49,443 737 12,232 (2,003) 76,803 Net loss for the - - - - (15) (126) (141) period Buyback of shares (244) - (1,062) 244 - - (1,062) At 30 September 2007 16,150 - 48,381 981 12,217 (2,129) 75,600 Unaudited Six months ended 30 September 2006 Share Share Special Capital Capital Retained Total £ Capital Premium Reserve Redemption Reserve Earnings '000 Account £'000 Reserve £'000 £'000 £'000 £'000 £'000 At 31 March 2006 6,935 272 19,167 653 11,201 (1,672) 36,556 Net loss for the - - - - (3,514) (164) (3,678) period Issue of shares 9,543 31,267 - - - - 40,810 Issue expenses - (938) - - - - (938) Share premium - (30,601) 30,601 - - - - account cancelled Issue expenses - - - - 37 - 37 written back At 30 September 16,478 - 49,768 653 7,724 (1,836) 72,787 2006 Audited Year ended 31 March 2007 Share Share Special Capital Capital Revenue Total Capital Premium Reserve Redemption Reserve Reserve £'000 Account £'000 Reserve £'000 £'000 £'000 £'000 £'000 At 31 March 2006 6,935 272 19,167 653 11,201 (1,672) 36,556 Net profit/(loss) - - - - 1,031 (331) 700 for the period Issue of shares 9,543 31,267 - - - - 40,810 Issue expenses - (938) - - - - (938) Share premium - (30,601) 30,601 - - - - account cancelled Issue expenses - - 39 - - - 39 written back Buyback of shares (84) - (364) 84 - - (364) At 31 March 2007 16,394 - 49,443 737 12,232 (2,003) 76,803 Balance Sheet as at 30 September 2007 (Unaudited) (Unaudited) (Audited) 30 30 31 March September September 2007 2006 2007 £'000 £'000 £'000 Non current assets Investments held at fair value through 74,695 73,081 78,088 profit or loss Current assets Other receivables 695 170 2,443 Cash and cash equivalents 1,184 538 - 1,879 708 2,443 Total assets 76,574 73,789 80,531 Current liabilities Other payables 974 742 2,635 Bank overdrafts - 260 1,093 974 1,002 3,728 Net assets 75,600 72,787 76,803 Equity attributable to equity holders Share capital 16,150 16,478 16,394 Special reserve 48,381 49,768 49,443 Capital redemption reserve 981 653 737 Capital reserve - realised 14,052 7,109 12,305 Capital reserve - unrealised (1,835) 615 (73) Revenue reserve (2,129) (1,836) (2,003) Total equity 75,600 72,787 76,803 Net asset value per share (note 5) 117.0p 110.4p 117.1p Cash Flow Statement for the six months ended 30 September 2007 (Unaudited) (Unaudited) (Audited) Six months ended Six months ended Year ended 30 September 30 September 2006 31 March 2007 2007 £'000 £'000 £'000 Net cash inflow/(outflow) 3,398 (39,107) (39,943) from operating activities (note 6) Net cash inflow/(outflow) 3,398 (39,107) (39,943) before financing Net cash (outflow)/inflow (1,010) 39,909 39,547 from financing activities Net increase/(decrease) in 2,388 802 (396) cash and cash equivalents Cash and cash equivalents (1,093) (420) (420) at start of period Realised loss on foreign (111) (104) (277) currency Cash and cash equivalents 1,184 278 (1,093) at period end Notes to the Interim Financial Statements 1. Accounting Policies The financial statements have been prepared under the historical cost convention, modified to include the valuation of investments at fair value, in accordance with applicable accounting standards and with the Statement of Recommended Practice `Financial Statements of Investment Trust Companies'. All of the Company's operations are of a continuing nature. This interim report is prepared in accordance with IAS 34 and on the basis of the accounting policies set out in the Company's Annual Report and Accounts as at 31 March 2007. 2. Income (Unaudited) (Unaudited) (Audited) 30 September 30 September 31 March 2007 2006 2007 £'000 £'000 £'000 Investment income 38 18 36 Bank interest 6 2 8 44 20 44 Notes to the Interim Financial Statements (continued) 3. Investment Management, Management and Performance Fees (Unaudited) (Unaudited) (Audited) 30 September 30 September 31 March 2007 2006 2007 £'000 £'000 £'000 Periodic fee 390 294 672 Performance fee accrual as at the 406 169 1,351 period end Performance fee provision as at (1,351) - - 31 March 2007 written back Irrecoverable VAT thereon (20) - 25 (575) 463 2,048 As at 30 September 2007 a performance fee of £169,000 (ex VAT) crystallised and became payable. 4. (Loss)/Earnings per Share The (loss)/earnings per share figure is based on the net loss for the six months of 141,000 (six months ended 30 September 2006: £3,678,000 loss; year ended 31 March 2007: £700,000 gain) and on 65,176,968 (six months ended 30 September 2006: 53,188,176 and year ended 31 March 2007: 59,520,000) shares, being the weighted average number of shares in issue during the period. The return per share detailed above can be further analysed between revenue and capital as follows: (Unaudited) (Unaudited) (Audited) 30 September 30 September 31 March 2007 2006 2007 £'000 £'000 £'000 Net revenue loss (126) (164) (331) Net capital (loss)/gain (15) (3,514) 1,031 Net total (loss)/gain (141) (3,678) 700 Weighted average number of shares 65,176,968 53,188,176 59,520,000 in issue during the period Pence Pence Pence Revenue loss per share (0.2) (0.3) (0.5) Capital (loss)/earnings per share - (6.6) 1.7 Total (loss)/earnings per share (0.2) (6.9) 1.2 Notes to the Interim Financial Statements (continued) 5. Net Asset Value per Share The net asset value per share is based on the net assets attributable to equity shareholders of £75,600,000 (30 September 2006: £72,787,000; 31 March 2007: £ 76,803,000) and on 64,599,263 (30 September 2006: 65,912,263; 31 March 2007: 65,577,263) shares, being the number of shares in issue at the period end. 6. Reconciliation of Profit/(Loss) Before Taxation to Net Cash Outflow From Operating Activities (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended 30 ended 30 September 2007 September 2006 31 March £'000 £'000 2007 £'000 (Loss)/profit before taxation (141) (3,678) 700 Loss/(gain) on investments held at 583 3,051 (3,096) fair value through profit or loss Net sales/(purchases) of 3,843 (38,622) (38,953) investments held at fair value through profit or loss (Increase) in other receivables (3) (16) - (Decrease)/increase in other (884) 158 1,406 payables Taxation on overseas income - - - Net cash inflow/(outflow) 3,398 (39,107) (39,943) 7. Transaction Costs Purchase and sale transaction costs for the six months ended 30 September 2007 were 178,000; year ended 31 March 2007: £378,000; six months ended 30 September 2006: £214,000. These costs comprise mainly stamp duty and broker commission. 8. VAT On 31 October 2007 the Association of Investment Companies announced that HM Revenue and Customs had confirmed to the Investment Management Association that investment trust investment management fees should no longer attract Value Added Tax (VAT). The Company is now taking steps to recover VAT paid to its previous investment manager, Close Investments Limited (formerly Close Finsbury Asset Management Limited) and the Company will take credit for any VAT recovered when any such recovery can be assessed with reasonable certainty. 9. Comparative Information The financial information contained in this interim report does not constitute statutory accounts as defined in section 240 of the Companies Act 1985. The financial information for the six months ended 30 September 2007 and 2006 has not been audited or reviewed by the auditors. Notes to the Interim Financial Statements (continued) The information for the year ended 31 March 2007 has been extracted from the latest published audited financial statements. The audited financial statements for the year ended 31 March 2007 have been filed with the Registrar of Companies. The report of the auditors on those accounts was unqualified, did not include a reference to any matters to which the auditors drew attention by way of emphasis without qualifying the report, and did not contain statements under section 237(2) or (3) of the Companies Act 1985. For The Biotech Growth Trust PLC Frostrow Capital LP, Company Secretary The Interim Report is available on the Company's website (www. Biotechgt.com) or from the Company Secretary and has been posted to shareholders END The Biotech Growth Trust PLC Interim Results for the six months ended 30 September 2007
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