Half-yearly Report

NEWS RELEASE For immediate release 29 November 2013 The Biotech Growth Trust PLC Unaudited Half Year Results for the six months ended 30 September 2013 COMPANY SUMMARY KEY STATISTICS 30 September 31 March 2013 2013 % change Net asset value per share 439.2p 371.7p +18.2 Share price 421.0p 368.0p +14.4 Discount of share price to net asset value 4.1% 1.0% - per share NASDAQ Biotechnology Index (sterling 1,352.6 1,099.0 +23.1 adjusted) Shareholders' funds £301.0m £239.6m +25.6 Gearing 8.1% N/A - No interim dividend is proposed. The following are attached: • Chairman's Statement • Review of Investments • Principal Contributors to and Detractors from Net Asset Value Performance • Portfolio • Income Statement • Statement of Changes in Equity • Statement of Financial Position • Cash Flow Statement • Notes to the Financial Statements • Interim Management Report This Announcement is not the Company's Half Year report. It is an abridged version of the Company's full Half Year report for the six months ended 30 September 2013. The full Half Year report will be sent to shareholders on 5 December 2013. The full Half Year report, together with a copy of this announcement, will also be available on the Company's website: www.biotechgt.com The Company's Half Year Report & Accounts for the six months ended 30 September 2013 has been submitted to the UK Listing Authority, and will shortly be available for inspection on the National Storage Mechanism (NSM): www.hemscott.com/nsm.do For further information please contact: Mark Pope, Frostrow Capital LLP 020 3008 4913 CHAIRMAN'S STATEMENT "….The Company's net asset value per share rose by 18.2% and the share price by 14.4% during the period." PERFORMANCE The Company's net asset value per share rose by 18.2% and the share price by 14.4% during the period, both significantly outperforming the broader market (the MSCI World Index rose by 1.0% in sterling terms during the period) but underperforming the benchmark, the NASDAQ Biotechnology Index, measured in sterling terms, which rose by 23.1%. The Company's underperformance of the benchmark was principally due to one holding, Infinity Pharmaceuticals, a small capitalisation biotechnology company, a significant holding in the portfolio, but not a large constituent of the benchmark. The company's share price fell following concern about the safety profile of their lead compound for the treatment of haematological cancers. Such dramatic share price movements are not uncommon for small capitalisation biotechnology companies that have a significant reliance on a single compound; additional data will be needed better to define the risk/benefit profile of this drug. Further information on investment performance and the outlook for the Company is given in the Review of Investments. CAPITAL STRUCTURE The Company's strong performance has continued to fuel demand for new shares. I am pleased to report that a total of 4,070,000 new shares were issued by the Company during the period and to the date of this report, always at a premium to the prevailing net asset value per share, raising £15.9 million of new funds for the Company. Our success in issuing new shares required the publication of a Prospectus by the Company in July. INVESTMENT OBJECTIVE AND POLICY Shareholder approval was obtained at a General Meeting of the Company held on 30 October 2013 to amend the Company's investment objective and policy. Both the Board and the Investment Manager believe that the Company's existing investment objective and policy constrained the Company's investment portfolio by limiting the majority of investee companies to those with a market capitalisation of less than U.S. $3 billion, which took no account of how the biotechnology sector has evolved over the years. The new investment objective and policy allows greater flexibility in the size of biotechnology companies in which the Company can invest. REGULATORY The Board intends to achieve compliance with the Alternative Investment Fund Managers Directive (the `Directive') by 22 July 2014. The Board, together with its advisers, is currently reviewing the options open to the Company and will endeavour to ensure that all documentation and arrangements to enable the Company to comply with the Directive are in place well in advance of the deadline. REVENUE AND DIVIDENDS The revenue loss for the period was £36,000 (six months ended 30 September 2012: profit of £18,000) and no interim dividend is declared (six months ended 30 September 2012: nil). OUTLOOK The development of new products and the prospect of merger and acquisition activity continue to be key drivers for the biotechnology sector. Our Investment Manager believes that large capitalisation biotechnology companies also offer good value opportunities due, in part, to positive earnings prospects for 2014 and beyond. Against this back-drop, the Board remains confident in the future performance of the sector and considers that the portfolio is well positioned to benefit from this positive outlook. THE RT HON LORD WALDEGRAVE OF NORTH HILL CHAIRMAN 29 NOVEMBER 2013 REVIEW OF INVESTMENTS PERFORMANCE REVIEW The Company's net asset value per share increased 18.2% during the six month period ended 30 September. This compares to a 23.1% increase in the Company's benchmark, the sterling-adjusted NASDAQ Biotechnology Index. The Company's share price increased 14.4% during the period. Top contributors to performance in the portfolio were Regeneron Pharmaceuticals, Incyte, Celgene, Gilead Sciences and Acadia Pharmaceuticals. • Regeneron shares appreciated due to strong sales of lead drug Eylea for wet age-related macular degeneration. Additionally, investor enthusiasm increased for their pipeline drug targeting PCSK9 for high cholesterol. Phase III data will be available in 2014, and this could represent a multi-billion dollar sales opportunity. • Incyte shares increased due to continued strong sales of Jakafi for Myelofibrosis and the release of new preliminary data showing that Jakafi may also play a role in the treatment of pancreatic cancer. This raises the possibility that Jakafi may be useful against a broader range of solid tumours. • Celgene shares appreciated over the period due to continued positive data releases for their drug apremilast for psoriasis and psoriatic arthritis and positive results of a Phase 3 study in front-line multiple myeloma for their drug Revlimid. Approval of Revlimid in the first-line setting in Europe represents a major sales expansion opportunity for the company. • Gilead Sciences shares appreciated over the period due to positive data releases for their hepatitis C drug sofosbuvir and positive trial results for their drug idelalisib in leukemia and lymphoma. • Acadia shares increased due to positive investor sentiment about the upcoming approval for pimavanserin for Parkinson's disease psychosis. Investors have also become more optimistic about the possibility of pimavanserin proving effective for psychosis associated with Alzheimer's disease, which would represent a much larger market opportunity. The largest losses were from positions in Infinity Pharmaceuticals, Dynavax Technologies, and Prosensa. • Shares in Infinity Pharmaceuticals declined due to the release of new safety data for IPI-145 that showed a higher than expected rate of infectious and respiratory adverse events. Additional patient experience will be required to better characterise the benefit/risk profile of IPI-145 compared to other agents in development. • Dynavax shares declined because the U.S. Food and Drug Administration (FDA) requested an additional safety trial prior to approval of their hepatitis B vaccine Heplisav, significantly delaying the launch of the vaccine. • Prosensa shares declined due to the failure of drisapersen for Duchenne muscular dystrophy. As Prosensa's entire pipeline is built on the same exon-skipping technology, the future of the company is uncertain. OUTLOOK The biotechnology sector performed strongly during the review period. As we previously detailed in our report at the year-end, major biotechnology companies as a group are experiencing a period of earnings reacceleration as significant new product launches are reinvigorating the outlook for these companies. For example, Biogen Idec recently launched Tecfidera for multiple sclerosis. The launch has exceeded all expectations, and the drug is well on its way to becoming a blockbuster. Gilead Sciences will soon launch sofosbuvir for hepatitis C. We expect this drug to be a multi-billion dollar drug and capture the majority of this market. Looking at valuations, the average 2015 price/earnings ratio of the four established major biotechnology companies is currently 15.8x. This is in-line with the average 2015 figure for major pharmaceutical companies, which is currently 15.2x. However, the long term earnings per share growth rate for major biotechnology companies is an estimated 18% vs. only 5% for major pharmaceutical companies. This argues that the biotechnology sector is still cheap relative to the pharmaceutical sector and we therefore expect continued strength from major biotechnology companies. Merger & Acquisition (M&A) activity has long been an important catalyst for the sector, particularly for the emerging biotechnology companies with mid- and late-stage products. Two holdings within the portfolio were recently acquired: Onyx Pharmaceuticals and Astex Pharmaceuticals. Onyx was acquired by Amgen primarily to obtain its recently launched myeloma drug, Kyprolis. Astex Pharmaceuticals was acquired by Otsuka for its cancer pipeline including its leukemia drug SGI-110. We find it encouraging that even though the sector has been revalued higher over the past two years, strategic acquirers still find companies to be attractive at these levels. Additionally it is notable that acquirers are being rewarded by investors for M&A. For example, Amgen's stock increased strongly after the acquisition of Onyx as the deal was positively received by investors as it will increase the company's long term growth potential. With increased investor interest in the biotechnology sector, the IPO market has been particularly strong compared to prior years. Thus far in 2013 there have been over 30 biotechnology IPOs. The Company participated in six IPOs during the period which contributed to performance. Finally we note that the sector will continue to have important catalysts to sustain the momentum in the sector. For 2014, we are expecting important pivotal data from a number of companies including Vertex Pharmaceuticals for its cystic fibrosis combination regimen, InterMune for its pulmonary fibrosis drug Esbriet, and Exelixis for its prostate cancer drug Cometriq. On the product launch front, in addition to sofosbuvir, important launches include Pharmacyclics' Ibutinib for chronic lymphocytic leukemia and mantle cell lymphoma, and BioMarin's Vimizim for Morquio syndrome. The number of holdings in the portfolio remains approximately 40. The Company's Investment Objective and Policy were recently amended to remove the restriction requiring the majority of assets to be invested in emerging biotechnology companies. This provides flexibility to increase allocation to major biotechnology when we find the investment case to be particularly compelling. We believe the fundamentals of the sector remain strong and look forward to updating investors in the future. SVEN BORHO ORBIMED CAPITAL LLC INVESTMENT MANAGER 29 NOVEMBER 2013 PRINCIPAL CONTRIBUTORS TO AND DETRACTORS FROM NET ASSET VALUE PERFORMANCE FOR THE SIX MONTHS TO 30 SEPTEMBER 2013 Contribution Contribution 2013 per share £'000 (pence)* Top Five Contributors 1 Regeneron Pharmaceuticals 8,962 13.3 2 Incyte 6,863 10.1 3 Celgene 4,969 7.3 4 Gilead Sciences 4,782 7.1 5 Acadia Pharmaceuticals 4,741 7.0 30,317 44.8 Bottom Five Detractors 1 Infinity Pharmaceuticals (15,023) (22.2) 2 Dynavax Technologies (2,585) (3.8) 3 Prosensa (1,243) (1.8) 4 Optimer Pharmaceuticals (738) (1.1) 5 Agios Pharmaceuticals (448) (0.7) (20,037) (29.6) * based on 67,630,199 ordinary shares being the weighted average number of shares in issue for the year ended 30 September 2013 Source: Frostrow Capital LLP PORTFOLIO AS AT 30 SEPTEMBER 2013 Fair Value % of Investments Country £'000 Investments Celgene United States 31,178 9.6 Gilead Sciences United States 28,177 8.7 Regeneron Pharmaceuticals United States 26,457 8.1 Amgen United States 26,396 8.1 Biogen Idec United States 19,478 6.0 Incyte United States 15,435 4.7 Mylan United States 13,270 4.1 Medivation United States 12,526 3.9 BioMarin Pharmaceutical United States 12,089 3.7 Vertex Pharmaceuticals United States 11,095 3.4 Top 10 investments 196,101 60.3 Illumina United States 9,730 3.0 InterMune United States 9,584 2.9 Alexion Pharmaceuticals United States 8,807 2.7 Infinity Pharmaceuticals United States 7,645 2.3 Cubist Pharmaceuticals United States 7,471 2.3 Techne United States 7,366 2.3 Exelixis United States 7,082 2.2 Impax Laboratories United States 6,050 1.9 Affymetrix United States 6,009 1.8 Onyx Pharmaceuticals United States 5,581 1.7 Top 20 investments 271,426 83.4 Portola Pharmaceuticals United States 5,402 1.7 Acadia Pharmaceuticals United States 5,290 1.6 Fluidigm United States 4,666 1.4 Ono Pharmaceutical Japan 4,592 1.4 Shire Ireland 4,516 1.4 Jazz Pharmaceuticals United States 4,089 1.3 Exact Sciences United States 3,669 1.1 Endo Health Solutions United States 2,946 0.9 Array Biopharma United States 2,919 0.9 Questcor Pharmaceuticals United States 2,865 0.9 Top 30 investments 312,380 96.0 All of the above investments are equities unless otherwise stated. PORTFOLIO (continued) AS AT 30 SEPTEMBER 2013 Fair Value % of Investments Country £'000 Investments Orbimed Asia Partners L.P. (unquoted) Far East 2,654 0.8 Bluebird Bio United States 2,195 0.7 Dynavax Technologies United States 1,776 0.6 ArQule United States 1,354 0.4 Synageva BioPharma United States 1,302 0.4 Avanir Pharmaceuticals United States 1,180 0.4 Bavarian Nordic Denmark 767 0.2 Neurocrine Biosciences United States 718 0.2 Esperion Therapeutics United States 708 0.2 Ophthotech United States 312 0.1 Total investments 325,346 100.0 All of the above investments are equities unless otherwise stated. INCOME STATEMENT for the six months ended 30 September 2013 (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended ended 30 30 31 March September September 2013 2013 2012 Revenue Capital Total Revenue Capital Total Revenue Capital Total Note £'000 £'000 £'000 £'000 £'000 £'000 £'000 £'000 £'000 Investment income Investment 2 477 - 477 328 - 328 570 - 570 income Total 477 - 477 328 - 328 570 - 570 income Gains and losses on investments Gains on - 43,772 43,772 - 30,873 30,873 - 80,714 80,714 investments held at fair value through profit or loss Exchange - 927 927 - (204 ) (204 ) - 92 92 gains/ (losses) on currency balances Expenses Investment 3 - 875 875 - (1,797 ) (1,797 ) - (4,586 ) (4,586 ) management, management and performance fees Other (469 ) - (469 ) (286 ) - (286 ) (566 ) - (566 ) expenses Profit 8 45,574 45,582 42 28,872 28,914 4 76,220 76,224 before finance costs and taxation Finance - (20 ) (20 ) - (13 ) (13 ) - (18 ) (18 ) costs Profit 8 45,554 45,562 42 28,859 28,901 4 76,202 76,206 before taxation Taxation (44 ) - (44 ) (24 ) - (24 ) (58 ) - (58 ) (Loss)/ (36 ) 45,554 45,518 18 28,859 28,877 (54 ) 76,202 76,148 profit for the period/ year Basic and 4 (0.1 ) 67.4p 67.3p 0.0p 46.1 p 46.1 p (0.1 ) 121.2 p 121.1p diluted p p (loss)/ earnings per share The Company does not have any income or expenses which are not included in the profit for the period. Accordingly the "profit/(loss) for the period" is also the "Total Comprehensive Income for the period", as defined in IAS 1 (revised) and no separate Statement of Comprehensive Income has been presented. All of the profit/(loss) and Total Comprehensive Income for the period is attributable to the owners of the Company. The total column of the statement is the Income Statement of the Company prepared in accordance with IFRS. The supplementary revenue and capital columns are presented for information purposes as recommended by the Statement of Recommended Practice issued by the Association of Investment Companies. All items in the above statement derive from continuing operations. No operations were acquired or discontinued in the period. STATEMENT OF CHANGES IN EQUITY (Unaudited) Six months ended 30 September 2013 Ordinary Share Capital Share Premium Special Redemption Capital Revenue Capital Account Reserve Reserve Reserve Reserve Total £'000 £'000 £'000 £'000 £'000 £'000 £'000 At 31 16,117 26,122 25,167 5,577 170,341 (3,708 ) 239,616 March 2013 Net profit - - - - 45,554 (36 ) 45,518 /(loss) for period Issue of 1,017 14,870 - - - - 15,887 new shares At 30 17,134 40,992 25,167 5,577 215,895 (3,744 ) 301,021 September 2013 (Unaudited) Six months ended 30 September 2012 Ordinary Share Capital Share Premium Special Redemption Capital Revenue Capital Account Reserve Reserve Reserve Reserve Total £'000 £'000 £'000 £'000 £'000 £'000 £'000 At 31 15,560 19,300 25,214 5,572 94,139 (3,654 ) 156,131 March 2012 Net profit - - - - 28,859 18 28,877 for period Issue of 209 2,135 - - - - 2,344 new shares Repurchase (5 ) - (47 ) 5 - - (47 ) of own shares At 30 15,764 21,435 25,167 5,577 122,998 (3,636 ) 187,305 September 2012 (Audited) Year ended 31 March 2013 Ordinary Share Capital Share Premium Special Redemption Capital Revenue Capital Account Reserve Reserve Reserve Reserve Total £'000 £'000 £'000 £'000 £'000 £'000 £'000 At 31 15,560 19,300 25,214 5,572 94,139 (3,654 ) 156,131 March 2012 Net profit - - - - 76,202 (54 ) 76,148 /(loss) for the year Issue of 562 6,822 - - - - 7,384 new shares Repurchase (5 ) - (47 ) 5 - - (47 ) of own shares At 31 16,117 26,122 25,167 5,577 170,341 (3,708 ) 239,616 March 2013 STATEMENT OF FINANCIAL POSITION as at 30 September 2013 (Unaudited) (Unaudited) (Audited) 30 30 31 March September September 2013 2012 2013 Note £'000 £'000 £'000 Non current assets Investments held at fair value 325,346 179,677 244,296 through profit or loss Current assets Other receivables 1,226 1,072 13,967 Cash and cash equivalents - 11,931 8,401 1,226 13,003 22,368 Total assets 326,572 192,680 266,664 Current liabilities Other payables 16,226 5,375 27,048 Bank overdraft 9,325 - - 25,551 5,375 27,048 Net assets 301,021 187,305 239,616 Equity attributable to equity holders Ordinary share capital 17,134 15,764 16,117 Share premium account 40,992 21,435 26,122 Special reserve 25,167 25,167 25,167 Capital redemption reserve 5,577 5,577 5,577 Capital reserve 215,895 122,998 170,341 Revenue reserve (3,744 ) (3,636 ) (3,708 ) Total equity 301,021 187,305 239,616 Net asset value per share 5 439.2p 297.0p 371.7p CASH FLOW STATEMENT for the six months ended 30 September 2013 (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended ended 30 30 31 March September September 2013 2012 2013 £'000 £'000 £'000 Net cash (outflow)/inflow from (34,540 ) 10,020 1,154 operating activities (note 6) Net cash (outflow)/inflow before (34,540 ) 10,020 1,154 financing Net cash inflow from financing 15,887 2,297 7,337 activities Net (decrease)/increase in cash and (18,653 ) 12,317 8,491 cash equivalents Cash and cash equivalents at start of 8,401 (182 ) (182 ) period Realised gains/(losses) on foreign 927 (204 ) 92 currency Cash and cash equivalents at period/ (9,325 ) 11,931 8,401 year end NOTES TO THE FINANCIAL STATEMENTS 1. ACCOUNTING POLICIES The condensed financial statements of the Company have been prepared in accordance with International Financial Reporting Standards ("IFRS"). These comprise standards and interpretations approved by the International Accounting Standards Board ("IASB"), together with interpretations of the International Accounting Standards and Standing Interpretations Committee approved by the International Accounting Standards Committee ("IASC") that remain in effect, to the extent that IFRS have been adopted by the European Union. The same accounting policies used for the year ended 31 March 2013 have been applied. 2. INCOME (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended ended 30 30 31 March September September 2013 2012 2013 £'000 £'000 £'000 Overseas income 477 328 570 Total income 477 328 570 3. INVESTMENT MANAGEMENT, MANAGEMENT AND PERFORMANCE FEES (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended ended 30 30 31 March September September 2013 2012 2013 £'000 £'000 £'000 Investment management fee 894 581 1,245 Management fee 410 271 583 Performance fee (written back)/charged (2,179) 945 2,758 in the period/year* (875) 1,797 4,586 * In accordance with the performance fee arrangements described on pages 17 and 18 of the Company's 2013 Annual Report, a performance fee of £579,000 was accrued at 30 September 2013 (30 September 2012: £2,320,000), crystallised and become payable as at that date (September 2012: nil). The performance fee amount of £2,179,000 which was written back as at 30 September 2013, represents outperformance generated as at 31 March 2013 which was not maintained during the period. NOTES TO THE FINANCIAL STATEMENTS (continued) 4. BASIC AND DILUTED (LOSS)/EARNINGS PER SHARE (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended ended 30 30 31 March September September 2013 2012 2013 £'000 £'000 £'000 The (loss)/earnings per share is based on the following figures: Net revenue (loss)/gain (36 ) 18 (54 ) Net capital gain 45,554 28,859 76,202 Net total gain 45,518 28,877 76,148 Weighted average number of shares in 67,630,199 62,541,679 62,887,103 issue during the period/year Pence Pence Pence Revenue (loss)/earnings per share (0.1 ) 0.0 (0.1 ) Capital earnings per share 67.4 46.1 121.2 Total earnings per share 67.3 46.1 121.1 5. NET ASSET VALUE PER SHARE The net asset value per share is based on the net assets attributable to equity shareholders of £301,021,000 (30 September 2012: £187,305,000; 31 March 2013: £ 239,616,000) and on 68,536,347 shares, (30 September 2012: 63,056,347; 31 March 2013: 64,466,347) being the number of shares in issue at the period end. NOTES TO THE FINANCIAL STATEMENTS (continued) 6. RECONCILIATION OF PROFIT BEFORE TAXATION TO NET CASH (OUTFLOW)/INFLOW FROM OPERATING ACTIVITIES (Unaudited) (Unaudited) (Audited) Six months Six months Year ended ended ended 30 30 31 March September September 2013 2012 2013 £'000 £'000 £'000 Profit before taxation 45,562 28,901 76,206 Gains on investments held at fair (44,699 ) (30,669 ) (80,806 ) value through profit or loss Net (sales)/purchases of investments (31,928 ) 11,128 3,185 Increase in other receivables (44 ) (47 ) (49 ) (Decrease)/increase in other payables (3,431 ) 707 2,618 Net cash (outflow)/inflow (34,540 ) 10,020 1,154 7. TRANSACTION COSTS Purchase and sale transaction costs for the six months ended 30 September 2013 were £359,000 (six months ended 30 September 2012: £196,000; year ended 31 March 2013: £436,000). These costs comprise mainly of commission costs. 8. COMPARATIVE INFORMATION The financial information contained in this half year report does not constitute statutory accounts as defined in section 435(1) of the Companies Act 2006. The financial information for the six months ended 30 September 2013 and 2012 has not been audited, or reviewed by the auditors. The information for the year ended 31 March 2013 has been extracted from the latest published audited financial statements. The audited financial statements for the year ended 31 March 2013 have been filed with the Registrar of the Companies. The report of the auditors on those accounts was unqualified, did not include a reference to any matters to which the auditors drew attention by way of emphasis without qualifying the report and did not contain statements under section 498 of the Companies Act 2006. INTERIM MANAGEMENT REPORT PRINCIPAL RISKS AND UNCERTAINTIES A review of the half year and the outlook for the Company can be found in the Chairman's Statement and in the Review of Investments. The principal risks faced by the Company fall into ten broad categories: objective and strategy; level of discount/premium; portfolio performance; operational and regulatory; market price risk; liquidity risk; shareholder profile; currency risk; the risk associated with the Company's loan facility; and credit risk. Information on each of these areas is given in the Business Review within the Annual Report and Accounts for the year ended 31 March 2013. In the view of the Board these principal risks and uncertainties are applicable to the remaining six months of the financial year as they were to the six months under review. RELATED PARTY TRANSACTIONS During the first six months of the current financial year, no transactions with related parties have taken place which have materially affected the financial position or the performance of the Company. GOING CONCERN The Directors believe, having considered the Company's investment objective, risk management policies, capital management policies and procedures, and the nature of the portfolio and the expenditure projections, that the Company has adequate resources, an appropriate financial structure and suitable management arrangements in place to continue in operational existence for the foreseeable future. For these reasons, they consider there is reasonable evidence to continue to adopt the going concern basis in preparing the accounts. DIRECTORS' RESPONSIBILITIES The Board of Directors confirms that, to the best of its knowledge: (i) the condensed set of financial statements contained within the Half Year Report has been prepared in accordance with applicable accounting standards including International Accounting Standards, (IAS) 34; and (ii) the interim management report and the Chairman's statement includes a fair review of the information required by 4.2.7R and 4.2.8R of the UK Listing Authority and Transparency Rules. The Half Year Report has not been reviewed or audited by the Company's auditors. The Half Year Report was approved by the Board on 29 November 2013 and the above responsibility statement was signed on its behalf by: THE RT HON LORD WALDEGRAVE OF NORTH HILL CHAIRMAN END Frostrow Capital LLP Company Secretary 29 November 2013
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