Holding(s) in Company

For filings with the FSA include the annex                                              
                                                                                        
For filings with issuer exclude the annex                                               
                                                                                        
                                                                                        
                                                                                        
TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi                                         
                                                                                        

 

1. Identity of the issuer or the underlying issuer                                      
of existing shares to which voting rights are             Biotech Growth Trust (The) PLC
attached:ii                                                                             
                                                                                        
2 Reason for the notification (please tick the appropriate box or boxes):               
                                                                                        
An acquisition or disposal of voting rights                                             
                                                                                        
An acquisition or disposal of qualifying financial instruments which may result         
in the acquisition of shares already issued to which voting rights are attached         
                                                                                        
An acquisition or disposal of instruments with similar economic effect to               
qualifying financial instruments                                                        
                                                                                        
An event changing the breakdown of voting rights                                        
                                                                                        
Other (please specify):                     Due to In-Specie transfer between          X
                                            funds.                                      
                                                                                        
3. Full name of person(s) subject to the             Prudential plc group of companies  
notification obligation:iii                                                             
                                                                                        
4. Full name of shareholder(s)                                                          
 (if different from 3.):iv                                                              
                                                                                        
5. Date of the transaction and date on                                                  
which the threshold is crossed or                            04 September 2012          
reached: v                                                                              
                                                                                        
6. Date on which issuer notified:                            05 September 2012          
                                                                                        
7. Threshold(s) that is/are crossed or                          See Item 13             
reached: vi, vii                                                                        
                                                                                        


 

8. Notified details:                                                                    
                                                                                        
A: Voting rights attached to shares viii, ix                                            
                                                                                        
Class/type of     Situation previous  Resulting situation after the triggering          
shares            to the triggering   transaction                                       
                  transaction                                                           
                                                                                        
if possible using Number    Number    Number   Number of voting      % of  voting rights
the ISIN CODE     of        of        of       rights                x                  
                  Shares    Voting    shares                                            
                            Rights                                                      
                                      Direct   Direct   Indirect xii Direct    Indirect 
                                               xi                                       
                                                                                        
  GB0000385517    2,100,953 2,100,953 Below 3% Below 3%              Below 3%           
                                                                                        
                                                                                        
                                                                                        

 

B: Qualifying Financial Instruments                                                     
                                                                                        
Resulting situation after the triggering transaction                                    
                                                                                        
Type of financial  Expiration Exercise/              Number of voting       % of voting 
instrument         date xiii  Conversion Period xiv  rights that may be     rights      
                                                     acquired if the                    
                                                     instrument is                      
                                                     exercised/ converted.              
                                                                                        
                                                                                        
                                                                                        

 

C: Financial Instruments with similar economic effect to Qualifying Financial           
Instruments xv, xvi                                                                     
                                                                                        
Resulting situation after the triggering transaction                                    
                                                                                        
Type of    Exercise Expiration   Exercise/     Number of voting rights   % of voting    
financial  price    date xvii    Conversion    instrument refers to      rights xix, xx 
instrument                       period xviii                                           
                                                                                        
                                                                                        
                                                                         Nominal   Delta
                                                                                        
                                                                                        
                                                                                        

 

Total (A+B+C)                                                                           
                                                                                        
Number of voting rights                  Percentage of voting rights                    
                                                                                        
Below 3%                                 Below 3%                                       
                                                                                        


 

9. Chain of controlled undertakings through which the voting rights and/or the          
financial instruments are effectively held, if applicable: xxi                          
                                                                                        
                                                                                        
                                                                                        
                                                                                        
                                                                                        

 

Proxy Voting:                                                                           
                                                                                        
10. Name of the proxy holder:                                                       N/A 
                                                                                        
11. Number of voting rights proxy holder will cease                                 N/A 
to hold:                                                                                
                                                                                        
12. Date on which proxy holder will cease to hold                                   N/A 
voting rights:                                                                          
                                                                                        

 

                                                                                        
13. Additional                                                                          
information:      Following an In-Specie transfer, there has been a change of interest  
                  in the exempt holdings which do not have a notifiable interest.       
                                                                                        
                                                                                        
                                                                                        
                  As per 5.1.2, the non-exempt holdings for Prudential plc have moved   
                  below a 3% threshold triggering this notification.                    
                                                                                        
                                                                                        
                                                                                        
                                                                                        
                                                                                        
                  James Todd / Mark Thomas                                              
14. Contact name:                                                                       
                  M&G Investment Management Limited                                     
                                                                                        
15. Contact       020 7548 2293 / 020 7548 3266                                         
telephone number: