Holding(s) in Company

TR-1: Standard form for notification of major holdings

1. Issuer Details

ISIN

GB0000385517

Issuer Name

THE BIOTECH GROWTH TRUST PLC

UK or Non-UK Issuer

UK

2. Reason for Notification

An acquisition or disposal of voting rights

3. Details of person subject to the notification obligation

Name

Brewin Dolphin Limited

City of registered office (if applicable)

Newcastle upon Tyne

Country of registered office (if applicable)

United Kingdom

4. Details of the shareholder

Full name of shareholder(s) if different from the person(s) subject to the notification obligation, above

City of registered office (if applicable)

Country of registered office (if applicable)

5. Date on which the threshold was crossed or reached

13-Mar-2023

6. Date on which Issuer notified

14-Mar-2023

7. Total positions of person(s) subject to the notification obligation

.	% of voting rights attached to shares (total of 8.A)	% of voting rights through financial instruments (total of 8.B 1 + 8.B 2)	Total of both in % (8.A + 8.B)	Total number of voting rights held in issuer
Resulting situation on the date on which threshold was crossed or reached	4.551581	0.000000	4.551581	1779234
Position of previous notification (if applicable)	5.006300	0.000000	5.006300

8. Notified details of the resulting situation on the date on which the threshold was crossed or reached

8A. Voting rights attached to shares

Class/Type of shares ISIN code(if possible)	Number of direct voting rights (DTR5.1)	Number of indirect voting rights (DTR5.2.1)	% of direct voting rights (DTR5.1)	% of indirect voting rights (DTR5.2.1)
GB0000385517		1779234		4.551581
Sub Total 8.A	1779234		4.551581%

8B1. Financial Instruments according to (DTR5.3.1R.(1) (a))

Type of financial instrument	Expiration date	Exercise/conversion period	Number of voting rights that may be acquired if the instrument is exercised/converted	% of voting rights
Sub Total 8.B1

8B2. Financial Instruments with similar economic effect according to (DTR5.3.1R.(1) (b))

Type of financial instrument	Expiration date	Exercise/conversion period	Physical or cash settlement	Number of voting rights	% of voting rights
Sub Total 8.B2

9. Information in relation to the person subject to the notification obligation

2. Full chain of controlled undertakings through which the voting rights and/or the financial instruments are effectively held starting with the ultimate controlling natural person or legal entities (please add additional rows as necessary)

Ultimate controlling person	Name of controlled undertaking	% of voting rights if it equals or is higher than the notifiable threshold	% of voting rights through financial instruments if it equals or is higher than the notifiable threshold	Total of both if it equals or is higher than the notifiable threshold
Brewin Dolphin Ltd	Brewin Nominees Limited A/C NOM	2.985390		2.985390%
Brewin Dolphin Ltd	Brewin Nominees Limited A/C GROSS	1.230267		1.230267%
Brewin Dolphin Ltd	Brewin Nominees Limited A/C CHARITY	0.165212		0.165212%
Brewin Dolphin Ltd	Brewin Nominees (Channel Islands) Limited - JPAL	0.064010		0.064010%
Brewin Dolphin Ltd	Brewin Nominees (Channel Islands) Limited - JNOM	0.008954		0.008954%
Brewin Dolphin Ltd	R & H Fund Services (Jersey) Ltd.	0.083614		0.083614%
Brewin Dolphin Ltd	The Corporation Of Lloyds	0.014134		0.014134%

10. In case of proxy voting

Name of the proxy holder

The number and % of voting rights held

The date until which the voting rights will be held

11. Additional Information

Figures based on shares in issue of 39,090,471

The indirect voting rights under (9) relate to shares held in client
portfolios, managed by those firms, under discretionary investment
management agreements.

12. Date of Completion

14/03/23

13. Place Of Completion

Newcastle upon Tyne