Preliminary Announcement of Audited Results

NEWS RELEASE 31 May 2011 Preliminary Audited Results for the year ended 31 March 2011 The Biotech Growth Trust PLC (Company Registration Number 3376377) today announces preliminary audited results for the year ended 31 March 2011. 31 March 31 March % change 2011 2010 Shareholders' funds (£'000) 120,818 120,417 +0.3 Net asset value per share 186.0p 182.6p +1.9 Share price 166.0p 175.8p -5.6 Discount of share price to net asset value 10.8% 3.7% - per share NASDAQ Biotechnology Index (sterling 647.9 618.1 +4.8 adjusted) Total expense ratio * 1.2% 1.2% - *Based on the average amount of shareholders' funds during the year - excludes performance fee accrued/written back -see note 3. For and on behalf of Frostrow Capital LLP - Company Secretary 31 May 2011 - ENDS - The following are attached: * Chairman's Statement * Review of Investments * Income Statement * Statement of Changes in Equity * Statement of Financial Position * Statement of Cash Flows * Notes to the Financial Statements For further information please contact: Alastair Smith, Frostrow Capital LLP 020 3 008 4911 Mark Pope, Frostrow Capital LLP 020 3 008 4913 Jo Stonier, Quill Communications 020 7758 2230 Chairman's Statement PERFORMANCE During the year ended 31 March 2011, the Company's net asset value per share rose by 1.9% compared to a rise of 4.8% in the Company's benchmark during the same period. The Company's share price, however, fell by 5.6%, as the discount of share price to net asset value per share widened from 3.7% at 31 March 2010 to 10.8% at the year-end. This disappointing result was due in part to the strong performance of a small number of stocks which were in the Index against which we measure our performance but which were not in our own portfolio. We also suffered from being underweight in some mid capitalisation stocks which performed particularly well in the second half of the year and overweight in major biotechnology companies which underperformed the mid and small capitalisation companies. A weakening of the U.S. dollar during the year had a negative impact on the Company's absolute performance. Further information on the Company's investments can be found in the Review of Investments. Active management of a portfolio will inevitably lead to periods of relative out and underperformance. For example in the two preceding financial years our net asset value per share rose by 32.4% and 33.4% respectively, substantially outperforming the Index throughout that period. RETURN PER SHARE AND DIVIDEND The total return per share amounted to 3.0p for the year (2010: return of 51.8p), comprising a revenue deficit of 0.5p per share (2010: deficit of 0.6p) and a capital gain of 3.5p (2010: gain of 52.4p). No dividend is recommended in respect of the year ended 31 March 2011(2010: Nil). GEARING Following a change in the Company's custodian in December 2009, the Company's borrowing requirements are met through a loan facility, negotiated on competitive terms, provided by the custodian Goldman Sachs & Co, New York. This loan facility was used by the Company at various times during the year but on 31 March 2011 it was undrawn. CAPITAL The Board has continued to implement its policy of active discount management and to buy back shares when necessary in the event of the market price being at a discount greater than 6% to the net asset value per share. During the year, a total of 1,005,180 shares was bought back for cancellation, at an average discount to net asset value per share of 7.9%. The cost was £1,601,000 (including expenses). As mentioned above, the discount of the Company's share price to the net asset value per share was 10.8% at the year-end, emphasising that the discount can sometimes temporarily exceed the target of 6%. This reflects the overall balance between supply and demand for the Company's shares in the secondary market and the volatility of the biotechnology asset class. The average month end share price discount during the year was 6.1% and the execution and timing of any share buy-backs will continue to be at the absolute discretion of the Board. Shareholder approval to renew the authority to buy-back shares will be sought at the Annual General Meeting. DEVELOPMENTS IN THE INVESTMENT TRUST SECTOR HM Treasury's review of the tax and company law rules affecting investment trusts set out in its consultation document last summer has now resulted in sensible and beneficial amendments which should be advantageous to the whole industry. These amendments include a softening of the rules so that inadvertent and minor breaches that are remedied without delay will not cause the investment trust concerned to suffer adverse tax consequences. Our trade association, the Association of Investment Companies (AIC), played a leading role in reaching this satisfactory conclusion of the review. The Alternative Investment Fund Managers Directive was passed into law by the European Parliament last summer, but there is much detail still to emerge before this Directive takes effect in 2013. It is, however, clear that much of the over-bureaucratic regulation first proposed has been abandoned in favour of more pragmatic measures and the AIC again played a major role in achieving this. OUTLOOK The outlook for most markets has tended to improve over the last two years, not least on account of the expansive monetary policies adopted by many central banks. The Company's share price has risen from 130.5p to 180.0p since 31 March 2009. Serious structural problems still persist, however, in many industrial countries, particularly in the United States and in Europe. The dangers of inflation remain another growing source of concern. OrbiMed, our Investment Manager, believes that the outlook for the healthcare sector is good although volatility in the sector may increase if the Republicans decide to reform the current U.S. healthcare bill. But healthcare shares in general, and mature biotechnology shares in particular, are at historically low levels as measured by criteria such as a company's price/ earnings to growth ratio and OrbiMed are well positioned to take advantage of the investment opportunities which arise. Continued merger and acquisition activity and the release of important product data will both be key drivers for the sector. In addition, there are a number of expected high profile and innovative product approvals due in 2011 which could prove very significant for the sector. Despite disappointing performance in the year under review your Board is confident that the Company is well positioned to take advantage of current market conditions. Our focus continues to be on the selection of stocks with strong prospects for capital enhancement and we continue to believe that the long term investor in our sector will be well rewarded. ANNUAL GENERAL MEETING The Annual General Meeting of the Company will be held at the Barber-Surgeons' Hall, Monkwell Square, Wood Street, London EC2Y 5BL on Thursday, 14 July 2011 at 12 noon, and we hope as many shareholders as possible will attend. This will be an opportunity to meet the Board and to receive a presentation from our Investment Manager. John Sclater, CVO Chairman Review of Investments The Company's net asset value per share increased by 1.9% during the year. A weakening of the U.S. dollar negatively impacted the Company's absolute performance by approximately 5%. The Company's benchmark index, the NASDAQ Biotechnology Index (measured on a sterling adjusted basis), rose 4.8% during this period. The underperformance is partially attributed to a relative overweight position in major biotechnology companies which underperformed the mid and small capitalisation companies during the year. The top contributors to performance in the portfolio were Ariad Pharmaceuticals, Genzyme, Pharmasset, Illumina, and Shire. Ariad reported positive results from two programmes during the year which drove positive share performance: Ponatinib showed strong activity against the treatment of refractory chronic myelogenous leukaemia and Ridaforolimus demonstrated a benefit in sarcoma. Genzyme was acquired by Sanofi-Aventis at a 40% premium to the price before rumours of the unsolicited bid emerged. Pharmasset reported positive results from early stage trials for two of its HCV (Hepatitis C) polymerase inhibitors, PSI-7977 and PSI-938. Over the course of the year, it has become clear that Pharmasset is a front-runner among the next "wave" of direct acting antiviral drugs for HCV, and has the potential to be the first company with an all-oral combination regimen for HCV. Illumina's share price performance was driven by the launch of the company's new HiSeq 2000 next generation sequencing system in early 2010, which exceeded sales expectations over the course of the fiscal year. There has been keen investor interest in next generation genetic sequencing for both research and diagnostic purposes and Illumina remains the leading company in that area. Shire's share price performance was driven by earnings upside due to manufacturing difficulties at a key competitor and the absence of broad generic competition to its legacy attention deficit disorder compound Adderall XR. The largest losses were from positions in Allos Therapeutics, Curis, Amgen, and Celgene. Allos' shares were weak as the launch of their drug Folotyn for peripheral T-cell lymphoma came in below estimates. Furthermore, they reported underwhelming data for Folotyn for the treatment of lung cancer, a key expansion indication. We continue to hold the shares as we believe that the reset expectations for Folotyn in 2011 are achievable. Curis reported negative data for their "hedgehog inhibitor" licensed to Roche in colorectal cancer. This failure suggests that the drug may be limited to the relatively small market of basal cell carcinoma, where it does possess dramatic activity. Amgen's shares remained subdued during the year due to a slower-than-anticipated launch of its osteoporosis drug Prolia, investor concerns about the company's capital allocation policy and continued headwinds for the company's anaemia franchise. Celgene's shares underperformed during the year as investors began to question the longer term growth potential of the company. Additionally, data presented in December caused some concern about the potential for Revlimid, Celgene's lead drug for myeloma, to cause secondary cancers and thus limit uptake in the maintenance setting. Outlook: new product momentum continues The outlook for new innovative products from the biotechnology sector remains strong. A number of the drugs approved or expected to be approved in 2011 have "blockbuster" potential (conventionally defined, a blockbuster is a drug with over $1 billion in annual sales). We would highlight four new products that will be launched in 2011: Benlysta, Esbriet, Telaprevir, and Ruxolitinib. * Benylsta, from Human Genome Sciences and partnered with GlaxoSmithKline, is an anti-BLyS antibody for the treatment of lupus, an autoimmune disease with high unmet need. It is the first drug to be approved in the United States for lupus in 50 years. * Esbriet, from InterMune, has been approved in Europe for idiopathic pulmonary fibrosis, a fatal lung disease with no other effective drug therapy. * Telaprevir, from Vertex Pharmaceuticals, is a protease inhibitor for Hepatitis C. This drug dramatically increases the cure rate compared with current standard of care and will greatly expand the number of patients treated annually for Hepatitis C. * Ruxolitinib, from Incyte, is a Janus kinase inhibitor for myelofibrosis, a progressive scarring of the bone marrow. The drug has shown impressive activity in reducing spleen size and improving symptoms of the disease. The number of holdings in the portfolio remains at approximately 40, exclusive of unquoted investments and warrants. The geographic distribution of assets is 90% North America, 9% Europe and 1% Asia. Currently approximately 45% of the Company's assets are invested in major biotechnology, and 55% are invested in emerging biotechnology. We believe that the level of high profile new drug launches, the favourable valuation of major biotechnology companies and the potential for continued merger and acquisition activity will drive strong performance in the coming year. Sven Borho OrbiMed Capital LLC Investment Manager Income Statement for the year ended 31 March 2011 2010 Revenue Capital Total Revenue Capital Total £000 £000 £000 £000 £000 £000 Income Investment income ( note 69 - 69 31 - 31 2) Other income ( note 2) - - - 34 - 34 Total income 69 - 69 65 - 65 Gains and losses on investments Gains on investments - 2,691 2,691 - 30,979 30,979 held at fair value through profit or loss Exchange gains/(losses) - 402 402 - (725) (725) on currency balances Expenses Investment management, - (752) (752) - (1,365) (1,365) management and performance fees ( note 3) Refund of VAT previously - - - - 168 168 paid on management fees Other expenses (398) - (398) (417) - (417) (Loss)/profit before (329) 2,341 2,012 (352) 29,057 28,705 finance costs and taxation Finance costs (11) - (11) (3) (13) (16) (Loss)/profit before (340) 2,341 2,001 (355) 29,044 28,689 taxation Taxation (1) - (1) - - - (Loss)/profit for the (341) 2,341 2,000 (355) 29,044 28,689 year Basic and diluted / (0.5)p 3.5p 3.0p (0.6)p 52.4p 51.8p (loss) earnings per share ( note 4) The Company does not have any income or expenses which are not included in the profit for the year. Accordingly, the "profit for the year" is also the "total comprehensive income for the period", as defined in IAS 1 (revised) and no separate Statement of Comprehensive Income has been presented. All of the profit and total comprehensive income for the period is attributable to the owners of the Company. The "Total" column of this statement represents the Company's Income Statement, prepared in accordance with International Financial Reporting Standards (IFRS). The "Revenue" and "Capital" columns are supplementary to this and are prepared under guidance published by the Association of Investment Companies. All items in the above statement derive from continuing operations. Statement of Changes in Equity For the year ended 31 March 2011 Share Share Special Capital Capital Revenue Total capital premium redemption £'000 account reserve reserve reserve £'000 £'000 reserve £'000 £'000 £'000 £'000 At 31 March 2010 16,490 19,298 32,021 4,642 50,970 (3,004) 120,417 Net profit/ (loss) - - - - 2,341 (341) 2,000 for the year Issue costs refunded - 2 - - - - 2 Buyback of shares (251) - (1,601) 251 - - (1,601) At 31 March 2011 16,239 19,300 30,420 4,893 53,311 (3,345) 120,818 For the year ended 31 March 2010 Share Share Special Capital Capital Revenue Total capital premium redemption reserve £'000 account reserve reserve £'000 £'000 £'000 reserve £'000 £'000 £'000 At 31 March 2009 12,824 - 33,800 4,307 21,926 (2,649) 70,208 Net profit/ (loss) - - - - 29,044 (355) 28,689 for the year Issue of shares 4,001 19,877 - - - - 23,878 Issue costs - (579) - - - - (579) Buyback of shares (335) - (1,779) 335 - - (1,779) At 31 March 2010 16,490 19,298 32,021 4,642 50,970 (3,004) 120,417 Statement of Financial Position As at 31 March 2011 2010 £'000 £'000 Non current assets Investments held at fair 128,346 132,618 value through profit or loss Current assets Other receivables 1,161 304 Cash and cash equivalents 5,691 - 6,852 304 Total assets 135,198 132,922 Current liabilities Other payables 14,380 4,016 Bank loan - 8,489 14,380 12,505 Net assets 120,818 120,417 Equity attributable to equity holders Ordinary share capital 16,239 16,490 Share premium account 19,300 19,298 Special reserve 30,420 32,021 Capital redemption reserve 4,893 4,642 Capital reserve 53,311 50,970 Revenue reserve (3,345) (3,004) Total equity 120,818 120,417 Net asset value per share 186.0p 182.6p ( note 5) Statement of Cash Flows For the year ended 31 March 2011 2010 £'000 £'000 Operating activities Profit before tax 2,001 28,689 Add back interest paid 11 16 Less: gain on investments (2,691) (30,979) held at fair value through profit or loss Add exchange (gains)/ (402) 725 losses on currency balances Purchases of investments (98,383) (109,571) held at fair value through profit or loss Sales of investments held 115,677 82,788 at fair value through profit or loss Increase in other (15) (17) receivables (Decrease)/increase in (810) 667 other payables Net cash inflow/(outflow) 15,388 (27,682) from operating activities before interest and taxation Interest paid (11) (16) Taxation paid (1) - Net cash inflow/(outflow) 15,376 (27,698) from operating activities Financing activities Refund of issue costs 2 - Issue of shares - 23,299 Buy-back of shares (1,600) (2,387) (Repayment)/drawdown of (8,489) 5,350 bank loan Net cash (outflow)/inflow (10,087) 26,262 from financing Increase/(decrease) in 5,289 (1,436) cash and cash equivalents Cash and cash equivalents - 2,161 at start of year Effect of foreign exchange 402 (725) rate changes Cash and cash equivalents 5,691 - at end of year Notes to the Financial Statements 1 Basis of Preparation This preliminary announcement of the Company has been prepared in accordance with International Financial Reporting Standards ("IFRS") and using the same accounting policies as those in the last published annual accounts, being those to 31 March 2010. 2 Income 2011 2010 £'000 £'000 Investment Income - 2 Money market dividends 69 29 Overseas income 69 31 Other operating income - 34 Interest receivable (including interest on VAT repayment from HMRC) Total Income 69 65 3 Investment Management, Management and Performance Fees Revenue Capital Total Revenue Capital Total 2011 2011 2011 2010 2010 2010 £'000 £'000 £'000 £'000 £'000 £'000 Investment - 711 711 - 544 544 Management fee Management fee - 322 322 - 247 247 Performance - (281) (281) - 574 574 fee (written back) /accrued - 752 752 - 1,365 1,365 Notes to the Financial Statements (continued) 4 Basic and diluted (loss)/earnings per share Total gain per share of 3.0p (2010: gain 51.8p) is based on the total gain attributable to equity shareholders of £2,000,000 (2010: gain £28,689,000). The revenue loss per share of 0.5p (2010 loss: 0.6p) is based on the revenue loss attributable to equity shareholders of £341,000 (2010: £355,000). The capital gain per share of 3.5p (2010: gain 52.4p) is based on the capital gain attributable to equity shareholders of £2,341,000 (2010: gain £ 29,044,000). The total gain, revenue loss and capital gain per share are based upon the weighted average number of shares in issue during the year of 65,687,388 (2010: 55,422,574). 5 Net asset value per share The net asset value per share is based on the net assets attributable to equity shareholders of £120,818,000 (2010: £120,417,000) and on 64,954,681 (2010: 65,959,861) shares in issue at 31 March 2011. 6 Financial information This preliminary statement is not the Company's statutory accounts. The above results for 2011 have been agreed with the Auditors and are an abridged version of the Company's full accounts which have not yet been filed with the Registrar of Companies. The 2011 accounts have been prepared in accordance with International Financial Reporting Standards ("IFRS"). The statutory accounts for the year end 31 March 2010 have been delivered to the Registrar of Companies and those for 31 March 2011 will be despatched to shareholders shortly. The 2011 accounts received an audit report which was unqualified, did not include a reference to any matter to which the auditors drew attention without qualifying the report, and did not contain statements under Section 498 of the Companies Act 2006. Frostrow Capital LLP Company Secretary 31 May 2011 - ENDS - The Biotech Growth Trust PLC
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