Director Share Dealings

Director Share Dealings

December 23, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) (the "Company")
announces that today Ordinary Shares ("Shares") and American Depository Shares
("ADSs") of the Company, as set out below, have been acquired for the
Non-Executive Directors, being the part of their total fees that are paid in
shares for the period of service from October 1 to December 31, 2013.

                         Type of Security(1)     Number of Shares/ADSs 
                                                                       
William Burns                  Shares                           230    
                                                                       
Dr. Steven Gillis               ADSs                             73    
                                                                       
Dr. David Ginsburg              ADSs                             72    
                                                                       
David Kappler                  Shares                           214    
                                                                       
Susan Kilsby                    ADSs                             56    
                                                                       
Anne Minto                     Shares                           272    
                                                                       
David Stout                     ADSs                             66    

(1) One ADS is equal to three Shares

The Shares and ADSs were acquired on the London Stock Exchange and NASDAQ
respectively at prices of £28.13 per Share and $137.74 per ADS.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a)
of the Disclosure and Transparency Rules.

Tony Guthrie
Deputy Company Secretary

For further information please contact:

Investor Relations                                                             
                                                                               
Eric Rojas                              [e-mail]     [phone]   
                                                                               
Sarah Elton-Farr                        [e-mail] [phone]   

Notes to editors

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal,
Internal Medicine and Regenerative Medicine and we are developing treatments
for symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas.

www.shire.com

                                                                      
Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Press Release                                     
                                                  
www.shire.com