Holding(s) in Company

Oxford Instruments plc has been notified today, pursuant to Section 198 of the
Companies Act 1985, that HBOS plc and its subsidiaries have a material interest
of 1,725,250 Ordinary £0.05p shares in our Company, which represents 3.548% of
the shares in issue.

The shares to which this notification relates are registered as follows:

           No of Shares              Fund       Registered Holder     
                                                                      
                23                    N/A      HSDL Nominees Limited     
                                                                      
           705,227                    2GDL     State Street Nominees     
                                              Limited                   
                                                                      
         1,020,000                    2GDG     State Street Nominees     
                                              Limited                   
                                                                      
         1,725,250