Holding(s) in Company

Oxford Instruments plc has been notified that Ameriprise Financial, Inc and its
group, of which Threadneedle Asset Management Holdings Limited is the ultimate
intermediate holding company in the UK has an interest in 2,495,780 Ordinary
Shares of 5p each which, represents 5.059% of the issued share capital of
Oxford Instruments plc.

The number of voting rights is also 2,495,780 (71,00 direct 0.144% and
2,424,780 indirect 4.915%).

The shares to which this notification relates are registered as follows:

                                                                       No of   
                                                                       Shares  
                                                                               
Chase Nominees Limited               A/C 41407                       375,000   
                                                                               
Littledown Nominees Limited          A/C 05577                       54,500    
                                                                               
Littledown Nominees Limited          A/C 05576                       825,000   
                                                                               
Littledown Nominees Limited          A/C 07197                       71,000    
                                                                               
Littledown Nominees Limited          A/C 07203                       42,000    
                                                                               
Littledown Nominees Limited          A/C 21667                       16,500    
                                                                               
Littledown Nominees Limited          A/C 34789                       55,000    
                                                                               
Littledown Nominees Limited          A/C 10496                       616,780   
                                                                               
Littledown Nominees Limited          A/C 10488                       260,000   
                                                                               
Littledown Nominees Limited          A/C 10490                       180,000