Holding(s) in Company

Oxford Instruments plc has been notified today that Schroders plc now holds
5,098,183 ordinary shares of 5p each, with indirect voting rights over
4,940,549 ordinary shares of 5p each. The voting rights indirectly held by
Schroders plc now represent 9.96% of the issued share capital of the Company.

The Registered Holders of these voting rights are as follows:

Schroder Investment Management Limited                4,589,951    9.25%
                                                                        
Schroder Investment Management North America            350,598    0.70%
Limited                                                                 
                                                                        

The shares referred to in the above table are held in portfolios managed by
those firms on a discretionary basis for clients under investment management
agreements.

15 July 2010

Susan Johnson-Brett

Company Secretary

Oxford Instruments plc

Tel: [phone]

Email: [e-mail]