Holding(s) in Company

TR-1: Notifications of Major Interests in Shares                               

 1. Identity of the issuer or the                 Oxford Instruments PLC       
    underlying issuer of existing shares                                       
    to which voting rights are attached:                                       

2: Reason for notification (yes/no)                                            
                                                                               
An acquisition or disposal of voting rights                              yes   
                                                                               
An acquisition or disposal of qualifying financial instruments which     no    
may result in the acquisition of shares already issued to which             
voting rights are attached                                
                                                                               
An acquisition or disposal of instruments with similar economic          no    
effect to qualifying financial instruments                                     
                                                                               
An event changing the breakdown of voting rights                         no    
                                                                               
Other (please specify):                                                  no    

3. Full name of person(s) subject to the            Kames Capital            
notification obligation:                                                                    
                                                                               
4. Full name of shareholder(s) (if                                             
different from 3.):                                                            
                                                                               
5. Date of the transaction (and date on             19th October 2012          
which the threshold                                                            
                                                                               
is crossed or reached):                                                        
                                                                               
6. Date on which issuer notified:                   23rd October 2012          
                                                                               
7. Threshold(s) that is/are crossed or              5%                 
reached:                                                                       

8: Notified Details                                                            
                                                                               
 A. Voting rights attached to shares                                           
                                                                               
   * Class/type of share If possible                GB0006650450               
              use ISIN code                                                    
                                                                               
Situation previous to the triggering transaction                               
                                                                               
   * Number of shares                   * Number of voting rights       
                                                                               
        2,772,850                               2,772,850                
                                                                               
Resulting situation after the triggering transaction                           
                                                                               
    * Number of           Number of voting rights            Percentage of     
        shares                                               voting rights     
                                                                               
                         Direct            Indirect       Direct     Indirect  
                                                                               
      1,803,391        1,803,391           932,258         3.21%      1.66%    

 B. Qualifying Financial Instruments                                           
                                                                               
Resulting situation after the triggering transaction                           
                                                                               
    Type of       Expiration      Exercise/     No. of voting   Percentage of  
   financial         date        conversion    rights that may  voting rights  
  instrument                     period/date     be acquired                   
                                                   (if the                     
                                                 instrument                    
                                                 exercised/                    
                                                 converted)                    
                                                                               


C: Financial Instruments with similar economic effect to Qualifying Financial   
Instruments                                                                     
                                                                                
Resulting situation after the triggering transaction                            
                                                                                
Type of financial Exercise Expiration Exercise/  Number of     % of voting      
instrument        price    date       Conversion voting        rights           
                                      period     rights                         
                                                 instrument                     
                                                 refers to                      
                                                               Nominal    Delta             
Contract for Difference                          75,524        0.13%      1                                         
                                                                                
                                                                                                                                                 

Total (A+B+C)                                                                  
                                                                               
Number of voting rights                      Percentage of voting rights       
                                                                               
      2,811,173                                       5.00%               

9. Chain of controlled undertakings through which the voting rights and/or the 
financial instruments are effectively held, if applicable:                     
                                                                               
Kames Capital:-                                                                
                                                                               
Kames Capital plc                                                              
Kames Capital Management Ltd                                                   
Kames Capital ICVC                                                             
Kames Capital VCIC                                                             

Proxy Voting:                                                                  
                                                                               
10. Name of the proxy holder:                Kames Capital                     
                                                                               
11. Number of voting rights proxy holder                                       
will cease to hold:                                                            
                                                                               
12. Date on which proxy holder will cease to                                   
hold voting rights:                                                            

13. Additional information:                                                    
                                                                               
14. Contact name:                       Susan Johnson-Brett,
                                        Company Secretary   
                                                                               
15. Contact telephone number:           01865 393324