Holding(s) in Company

For filings with the FSA include the                                           
annex                                                                          
                                                                               
For filings with issuer exclude the                                            
annex                                                                          
                                                                               
TR-1: NOTIFICATION OF MAJOR INTEREST IN SHARESi                                
                                                                               
1. Identity of the issuer or the underlying PHSC PLC                           
issuer                                                                         
of existing shares to which voting rights                                      
are                                                                            
attached: ii                                                                   
                                                                               
2 Reason for the notification (please tick the appropriate box or boxes):      
                                                                               
An acquisition or disposal of voting rights                                    
                                                                               
An acquisition or disposal of qualifying financial instruments which           
may result in the acquisition of shares already issued to which voting         
rights are attached                                                            
                                                                               
An acquisition or disposal of instruments with similar economic effect         
to qualifying financial instruments                                            
                                                                               
An event changing the breakdown of voting rights                               
                                                                               
Other (please                Change of Investment Manager                 X    
specify):                                                                      
                                                                               
3. Full name of person(s) subject to         AXA Investment Managers SA        
the                                                                            
notification obligation: iii                                                   
                                                                               
4. Full name of shareholder(s)                                                 
(if different from 3.):iv                                                      
                                                                               
5. Date of the transaction and date                01 March 2012               
on                                                                             
which the threshold is crossed or                                              
reached: v                                                                     
                                                                               
6. Date on which issuer notified:                   3 April 2012               
                                                                               
7. Threshold(s) that is/are crossed                    5.00 %                  
or                                                                             
reached: vi, vii                                                               

8. Notified details:                                                          
                                                                              
A: Voting rights attached to shares viii, ix                                  
                                                                              
Class/type of  Situation         Resulting situation after the triggering     
shares         previous          transaction                                  
               to the triggering                                              
               transaction                                                    
if possible                                                                   
using          Number   Number   Number    Number of voting  % of voting      
the ISIN CODE  of       of       of shares rights            rights x         
               Shares   Voting                                                
                        Rights   Direct    Direct   Indirect Direct   Indirect
                                           xi       xii                       
                                                                              
GB0033113456   641 509  641 509  0         0        0        0.00 %   0.00 %  

B: Qualifying Financial Instruments                                             
                                                                                
Resulting situation after the triggering transaction                            
                                                                                
Type of financial Expiration Exercise/           Number of voting  % of voting  
instrument        date xiii  Conversion Period   rights that may   rights       
                             xiv                 be                             
                                                 acquired if the                
                                                 instrument is                  
                                                 exercised/                     
                                                 converted.                     
                                                                                
C: Financial Instruments with similar economic effect to Qualifying Financial   
Instruments xv, xvi                                                             
                                                                                
Resulting situation after the triggering transaction                            
                                                                                
Type of       Exercise  Expiration Exercise/  Number of voting   % of voting    
financial     price     date xvii  Conversion rights instrument  rights xix, xx 
instrument                         period     refers to                         
                                   xviii                                        
                                                                                
                                                                 Nominal  Delta 
                                                                                
                                 Total (A+B+C)                                  
                                                                                
        Number of voting rights               Percentage of voting rights       
                                                                                
                   0                                     0.00 %                 

9. Chain of controlled undertakings through which the voting rights and/or the 
financial instruments are effectively held, if applicable: xxi                 
                                                                               
Proxy Voting:                                                                  
                                                                               
10. Name of the proxy holder:                                                  
                                                                               
11. Number of voting rights proxy holder will                                  
cease                                                                          
to hold:                                                                       
                                                                               
12. Date on which proxy holder will cease to hold                              
voting rights:                                                                 
                                                                               
                                                                               
13. Additional information:                                                    
                                                                               
14. Contact name:                      Sami BEKKALI                            
                                                                               
15. Contact telephone number:          [phone]