Holding(s) in Company

TR-1: NOTIFICATION OF MAJOR INTERESTS IN SHARES                                
                                                                               
1. Identity of the issuer or the underlying     Proteome Securities Plc        
issuer of existing shares to which voting                                      
rights are attached:                                                           
                                                                               
2. Reason for the notification (please tick the appropriate box or             
boxes)                                                                         
                                                                               
An acquisition or disposal of voting rights                              Yes   
                                                                               
An acquisition or disposal of financial instruments which may result           
in the acquisition of shares already issued to which voting rights are         
attached                                                                       
                                                                               
An event changing the breakdown of voting rights                               
                                                                               
3. Full name of person(s) subject to the        Cubana Investments Limited     
notification obligation:                                                       
                                                                               
4. Full name of shareholder(s) (if different                                   
from 3.):                                                                      
                                                                               
5. Date of the transaction (and date on which   01 April 2008                  
the threshold is crossed or reached if                                         
different):                                                                    
                                                                               
6. Date on which issuer notified:               01 April 2008                  
                                                                               
7. Threshold(s) that is/are crossed or reached: >8%                            
                                                                               
8. Notified details:                                                           

A: Voting rights attached to shares                                            
                                                                               
Class/type     Situation previous        Resulting situation after the triggering       
of shares      to the Triggering                       transaction                                    
                 transaction                                                        
if possible                                                                    
using the                                                                      
ISIN CODE                                                                      

              Number of    Number of    Number of      Number of voting         % of voting                   
                Shares      Voting       shares             rights                 rights                        
                            Rights                                                               
                                                     Direct     Indirect     Direct     Indirect

GB0003104196 10,374,272   10,374,272   10,531,272  10,531,272  10,531,272     8.01% 
                                                                           
                                                                                  

B: Financial Instruments                                                       
                                                                               
Resulting situation after the triggering transaction                           
                                                                               
Type of         Expiration  Exercise/          Number of voting    % of voting 
financial       date        Conversion Period/ rights that may be  rights      
instrument                  Date               acquired if the                 
                                               instrument is                   
                                               exercised/                      
                                               converted                       
                                                                               
N/A             N/A         N/A                N/A                 N/A         

Total (A+B)                                                                    
                                                                               
Number of voting rights                % of voting rights                      
                                                                               
10,531,272                             8.01                                    

9. Chain of controlled undertakings through which the voting rights and/or the 
financial instruments are effectively held, if applicable:                     
                                                                               
N/A                                                                            

Proxy Voting:                                                                  
                                                                               
10. Name of the proxy holder:                      N/A                         
                                                                               
11. Number of voting rights proxy holder will      N/A                         
cease to hold:                                                                 
                                                                               
12. Date on which proxy holder will cease to hold  N/A                         
voting rights:                                                                 
                                                                               
13. Additional Information        Contact name: James Malthouse                
                                                                               
                                  Contact Telephone number: [phone]    

Note: Annex should only be submitted to the FSA not the issuer

Annex: Notification Of Major Interests In Shares

A: Identity of the person or legal entity subject to the notification          
obligation                                                                     
                                                                               
Full name (including legal form for legal   Cubana Investments Limited         
entities)                                                                      
                                                                               
Contact address (registered office for      PO Box 957, Offshore Incorporations
legal entities)                             Centre, Road Town, Tortola, British
                                            Virgin Islands                     
                                                                               
Other useful information (at least legal                                       
representative for legal persons)                                              


B: Identity of the notifier, if applicable                                     
                                                                               
Full name                                   Mirza Rahman                       
                                                                               
Contact address                             2 Battery Road, #26-01 Maybank     
                                            Tower, Singapore 049907            
                                                                               
Phone number                                [phone] :                     
                                            [e-mail]              
                                                                               
Other useful information (e.g. functional   Compliance Officer                 
relationship with the person or legal                                          
entity subject to the notification                                             
obligation)                                                                    


C: Additional information