Notifiable Interest

Proteome Sciences Plc ("the Company")                     

                              Notifiable Interest                              

                                                                               

A form TR-1 containing the following information has been received by the
Company.

TR-1 notification of major interests in shares

1. Identity of the issuer or the underlying issuer of existing shares to which
voting rights are attached:

Proteome Sciences Plc

2. Reason for the notification

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Crédit Agricole Cheuvreux International Ltd

4. Full name of shareholder(s) (if different from 3):

N/A

5. Date of the transaction (and date on which the threshold is crossed or
reached if different):

17 April 2007

6. Date on which issuer notified:

19 April 2007

7. Threshold(s) that is/are crossed or reached:

Holding after transaction went through percentage threshold

8. Notified details:

A: Voting rights attached to shares

Class/type   Situation previous to   Resulting situation after the triggering    
of shares    Triggering transaction  transaction                                 
                                                                                 
if possible                          Notification required under DTR transitional
using ISIN                           provision 7                                 
CODE                                                                             
             Number of Number of     Number of Number of voting   % of voting    
             Shares    Voting Rights shares    rights             rights         
                                                                                 
                                                                                 
                                                                                 
                                     Direct    Direct    Indirect Direct Indirect
                                                                                 
                                                                                 
                                                                                 
Ordinary     9,217,552 9,217,552     9,162,552 9,162,552 N/A      6.96%  N/A     
shares                                                                           
                                                                                 
GB0003104196                                                                     
                                                                                 

B: Financial Instruments

Resulting situation after the triggering transaction                           
                                                                               
                                                                               
                                                                               
Type of     Expiration Exercise/     Number of voting rights that may   % of   
financial   date       Conversion    be acquired if the instrument is   voting 
instrument             Period/ Date  exercised/ converted               rights 
                                                                               
                                                                               
                                                                               
N/A         N/A        N/A           N/A                                N/A    
                                                                               

Total (A+B)

Number of voting rights % of voting rights                                        
                                          
9,162,552               6.96%             
                                          
9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

SAS Rue La Boétie

Crédit Agricole SA

Calyon SA

Crédit Agricole Cheuvreux SA

10. Name of the Proxy holder:

N/A

11. Number of voting rights proxy holder will cease to hold:

N/A

12. Date on which proxy holder will cease to hold voting rights:

N/A

13. Additional information:

N/A

14. Contact name:

Karen Browne

15. Contact telephone number:

020 7214 5282