CTA Approval for SCIB1

5 May 2010

                                                                   GB00B39J5N63

                             Scancell Holdings Plc                             

                         (`Scancell' or the `Company')                         

           Clinical Trial Approval for SCIB1 melanoma vaccine study            

Scancell Holdings Plc, (PLUS:SCLP), the developer of therapeutic cancer
vaccines, is pleased to announce that its proposal to conduct a Phase I
clinical trial on SCIB1, its DNA ImmunoBody® vaccine being developed for the
treatment of melanoma, has been approved by the Gene Therapy Advisory Committee
(`GTAC') and by the Medicines and Healthcare products Regulatory Agency
(`MHRA') Medicines Division. In addition, Scancell's partner Ichor Medical
Systems (`Ichor') has obtained the required parallel approval from the MHRA
Devices Division for the use of Ichor's TriGridâ„¢ electroporation delivery
device to administer SCIB1 to patients participating in the trial of SCIB1.

Recruitment for the Phase I clinical trial of SCIB1 is expected to commence
shortly at three leading UK hospital centres in Nottingham, Manchester and
Newcastle.

SCIB1 is a novel DNA ImmunoBody® vaccine being developed using Scancell's
patented ImmunoBody® technology for the treatment of melanoma. ImmunoBody®
vaccines generate the high-avidity T-cells that kill cancer cells, which may
overcome the current limitations of most cancer vaccines. In vivo
electroporation is widely regarded as an effective method of enhancing the
potency of DNA vaccines by up to 100-fold compared to conventional methods of
delivery. Scancell is confident that TriGridâ„¢ will provide the most effective
delivery system for its SCIB1 melanoma vaccine as it enters clinical trials.

Advanced melanoma currently has a very poor prognosis with late stage (stage
IV) disease having a median survival of approximately six months. According to
the World Health Organisation, 132,000 melanoma skin cancers occur globally
each year and the incidence is increasing, especially in the United States,
Europe and Australia.

David Evans, Chairman of Scancell, commented:

"With the approvals from GTAC and MHRA in place Scancell will commence the
Phase I clinical trial of our first therapeutic cancer vaccine SCIB1 during
this second quarter which is exactly on track with our programme and marks a
significant step for the Company. We look forward to updating shareholders
again in due course."

A copy of this announcement is available for download on the Company's website
at http://www.scancell.co.uk/

The Directors of the issuer accept responsibility for this announcement.

                                    -ENDS-                                     

For further information contact:

Professor Lindy Durrant      Scancell Holdings Plc  + 44 (0)207 245 1100    
                                                                            
John Bick/Kirsty Corcoran    Hansard Communications + 44 (0)207 245 1100    
                                                                            
                                                    + 44 (0)7872 061 007    
                                                                            
Ross Andrews/Tom Rowley      Zeus Capital           + 44 (0)161 831 1512    


About Scancell

Scancell is developing novel therapeutic vaccines for the treatment of cancer
and infectious diseases based on its groundbreaking ImmunoBody® technology
platform. Scancell's first cancer vaccine, SCIB1, is being developed for the
treatment of melanoma and will enter clinical trials in 2010.

Treating cancer by vaccination allows small non-toxic doses of a vaccine to be
administered to a patient, stimulating an immune response. Effective cancer
vaccines need to target dendritic cells to stimulate both parts of the cellular
immune system; the helper cell system where inflammation is stimulated at the
tumour site; and the cytotoxic T-lymphocyte or CTL response where immune system
cells are primed to recognise and kill specific cells.

A limitation of many cancer vaccines currently in development is that they
cannot specifically target dendritic cells in vivo. Several groups have
demonstrated successful vaccination by growing dendritic cells ex vivo, pulsing
them with tumour antigens and re-infusing them. However, this procedure is
patient specific, time consuming and expensive. Scancell has developed its
breakthrough patent protected ImmunoBody® technology to overcome these
limitations.

An ImmunoBody® is a DNA vaccine encoding a human antibody or fusion protein
engineered to express helper cell and CTL epitopes from tumour antigens
over-expressed by cancer cells. Antibodies are ideal vectors for carrying T
cell epitopes from tumour antigens as they can effectively target dendritic
cells via their Fc receptors, allowing efficient stimulation of high avidity
and high frequency helper and CTL responses.

The ImmunoBody® technology can be adapted to provide the basis for treating any
tumour type and may also be of potential utility in the development of vaccines
against hepatitis, HIV and other chronic infectious diseases.

About Ichor

Ichor Medical Systems' TriGridâ„¢ Delivery System is the first integrated and
fully automated system for electroporation-mediated DNA administration. Ichor,
a privately-held biotech company based in San Diego, CA, is collaborating with
partners on three continents in a wide range of studies to test the TriGridâ„¢ as
an enabling platform for delivery of DNA drugs and vaccines to treat diseases
such as pandemic flu, hepatitis, HIV, melanoma, multiple sclerosis, and others.
The TriGridâ„¢ is also being tested by the U.S. military as an efficient means of
delivering anti-bioterrorism agents.