Placing to raise £1.73 million
30 June 2011
Scancell Holdings Plc
Subdivision of share capital and Placing to raise £1.73 million
Scancell Holdings plc, (`Scancell' or the `Company') the developer of
therapeutic cancer vaccines, is pleased to announce the following:
* The proposed subdivision of each Existing Ordinary Share of 1p into 10 new
Ordinary Shares of 0.1p each (the "Subdivision"); and
* A placing to raise £1.73 million, before costs, by means of the issue of
34,575,410 new Ordinary Shares at 5 pence per share (the "Placing") to fund
the working capital of the Company.
The Directors consider the Placing and Subdivision to be in the best interests
of the Company and its Shareholders as a whole. Since the Placing and
Subdivision are conditional on the Company obtaining Shareholders' approval the
Directors have therefore convened a General Meeting for 10.45 a.m. on 25 July
2011 in order to allow Shareholders to consider, and, if thought fit, approve
the Resolutions.
Professor Lindy Durrant, commented:
"We believe that, following completion of the Placing, we will have sufficient
funding to complete the Phase I trials of our melanoma treatment and to advance
the development of our series of new ImmunoBody® cancer vaccines to the
pre-clinical proof of principle stage. After the Phase I clinical trial has
been completed, and if the data is positive, the Company will seek to generate
revenues from a commercial deal on the ImmunoBody® technology and will continue
with the Phase II clinical trial. A successful outcome should present Scancell
as an excellent acquisition opportunity with an exit remaining firmly on the
agenda following the completion of the Phase II trial, expected early 2013."
Enquiries:
Scancell Holdings Plc + 44 (0)207 245 1100
Professor Lindy Durrant/Dr Richard Goodfellow
Hansard Communications + 44 (0)207 245 1100
Adam Reynolds/Guy McDougall
Zeus Capital - Nominated Adviser + 44 (0)161 831 1512
Ross Andrews/Tom Rowley
XCAP Securities Plc - Broker +44 (0) 207 101 7070
John Belliss/Parimal Kumar
Below are extracts from the Circular which will be sent to Shareholders today.
The full Circular will be available on the Company's website:
www.scancell.co.uk
KEY STATISTICS
Existing Share Capital
Total number of Existing Ordinary Shares at the date of this announcement
15,951,790
Subdivision
Number of Ordinary Shares in issue immediately following the Subdivision
159,517,900
Placing
Placing Price 5 pence
Number of Placing Shares to be issued pursuant to the Placing 34,575,410
Placing Shares as a percentage of the Enlarged Share Capital 17.8%
Gross proceeds of the Placing £1.73 million
Net proceeds of the Placing (after costs and expenses) £1.52 million
Upon Admission
Total number of Ordinary Shares in issue immediately following Admission
194,093,310
Market Capitalisation of the Company following Admission at the Placing Price £
9.70 million
ISIN Number following Admission GB00B63D3314
SEDOL following Admission B63D331
EXPECTED TIMETABLE OF PRINCIPAL EVENTS
Publication date of the Circular to Shareholders 30 June 2011
Latest time and date for receipt of completed Forms of Proxy for the GM 10.45
a.m. on 21 July 2011
General Meeting 10.45 a.m. on 25 July 2011
Record Date and time for implementation of the Subdivision 5.30 p.m. on 25 July
2011
Subdivision becomes effective 8.00 a.m. on 26 July 2011
CREST accounts credited with new Ordinary Shares 8.00 a.m. on 26 July 2011
Admission and commencement of dealings in the Placing Shares 8.00 a.m. on 26
July 2011
Share certificates for new Ordinary Shares posted to certificated Shareholders
by 9 August 2011
Notes
1. References to time in this announcement are to London time.
2. If any of the above times or dates should change, the revised times and/or
dates will be notified to Shareholders by an announcement on an RIS.
1. Introduction
The Company is pleased to announce a placing to raise £1.73 million by means of
the issue of 34,575,410 new Ordinary Shares at 5 pence per share to provide
additional working capital for the Group.
The Placing is conditional upon the Company's Shareholders passing resolutions
to subdivide each Existing Ordinary Share into 10 new ordinary shares of 0.1p
each, to grant the Board authority to allot the Placing Shares and to disapply
statutory pre-emption rights which would otherwise apply to the allotment of
the Placing Shares. The Placing is also conditional upon Admission. The Placing
has not been underwritten.
As such, the Directors have convened a General Meeting for 10.45 a.m. on 25
July 2011 in order to allow Shareholders to consider, and, if thought fit, pass
the Resolutions.
The purpose of the Circular, to be sent to Shareholders later today, is to
provide you with information regarding the Placing and Subdivision, to explain
why the Directors consider the Proposals to be in the best interests of the
Company and its Shareholders as a whole and to seek Shareholders' approval for
the Resolutions in order that the Placing and Subdivision can be effected.
The Circular also contains the Directors' recommendation that you vote in
favour of the Resolutions to be proposed at the GM.
2. Scancell
Overview
Scancell is a biopharmaceutical company focused on the cancer therapeutics
market and is developing a series of DNA vaccines for the treatment of cancer
based on its patented ImmunoBody® platform, which has the potential to overcome
many of the limitations of conventional approaches to the development of cancer
vaccines.
Cancer remains one of the world's most significant diseases and although there
have been considerable advances in the treatment of cancer over the last
decade, a high proportion of patients still die as a result of the disease. A
key challenge in the fight against cancer and the development of effective
cancer vaccines is overcoming the tumour's ability to `mask' itself from the
body's natural defence mechanism - the immune system.
Scancell's mission is to develop therapeutic cancer vaccines that stimulate the
patient's immune system to mount an active response to `reject' or kill the
growing tumour.
In June 2010, the Company commenced a Phase I/IIa clinical trial in humans for
its lead therapeutic melanoma vaccine, SCIB1, that has repeatedly shown good
anti-tumour effects in animal studies. The trial is expected to be completed in
2013. The Directors believe that a positive outcome would enable the Company to
position itself for a trade sale to one of the leading pharmaceutical or
biotechnology companies operating in the oncology market.
Scancell has also made progress in the development of its ImmunoBody®
technology platform, and several prototype vaccines have been identified with
the potential for further development. The most advanced of these prototype
vaccines has, in combination with Homspera®, an adjuvant developed by
ImmuneRegen BioSciences, Inc.®, produced encouraging anti-tumour results in
animal models, as announced earlier today.
The vaccine, known as SCIB2, stimulates immune responses to the lung cancer
antigen NY-ESO-1 and may also have potential utility in oesophageal, liver,
gastric, prostate, ovarian and bladder cancers. These results provide further
evidence that ImmunoBody® technology may have the ability to augment the immune
responses necessary to treat cancer effectively.
The Directors intend to license the Company's ImmunoBody® technology and
products to companies working in the therapeutic cancer vaccine field. The
manipulation and enhancement of patients' immune systems is also relevant to
the treatment of chronic infectious disease. Although Scancell does not intend
to venture outside the oncology arena itself, it also intends to license its
ImmunoBody® technology to companies working in the chronic infectious disease
area.
Update on clinical trials
During 2010 and 2011, data emerged from studies of two new treatments for
advanced melanoma patients: firstly, a study of vemurafenib, a BRAF inhibitor
being developed by Roche, demonstrated a survival benefit versus decarbazine
(although the magnitude and duration of the response is not yet fully
established ) in patients with the BRAF gene mutation (up to 50 per cent. of
patients); secondly, a Phase III trial of the anti-CTLA4 monoclonal antibody
ipilimumab demonstrated a prolongation of survival from 6 to 10 months.
Ipilimumab has now been approved by the US FDA for use in patients with
advanced metastatic melanoma. Both new products, although representing an
advance in the treatment of metastatic melanoma, cause serious and, in the case
of ipilimumab, potentially lifethreatening side effects in a significant number
of patients. Despite these advances there is therefore still a profound need
for more effective and safer treatments of this devastating disease.
The recruitment rate of patients for Scancell's Phase I clinical trial has been
slower than anticipated, it is thought that this is because, with these two
treatments available, some otherwise suitable patients have been recruited into
BRAF studies or offered ipilimumab on a compassionate use basis.
As announced on 28 January 2011, the Company was pleased to have obtained
approval from the Gene Therapy Advisory Committee (`GTAC') and the Medicines
and Healthcare products Regulatory Agency (`MHRA') Medicines Division to open a
fourth trial centre in Leeds. This approval along with that of Scancell's
protocol amendment allowing inclusion of all Stage III and Stage IV malignant
melanoma patients, is expected to improve the rate of recruitment in the second
half of 2011 and thereafter.
These earlier stage patients are also anticipated to make better immune
responses (as late stage cancer patients often have weakened immune systems)
which should have a positive effect on the trial outcome. Scancell's first
group of patients receiving the lowest dose of SCIB1 has now been evaluated by
the Cohort Review Committee. The review of the safety data of the first three
patients after three treatments has resulted in the approval of an escalation
of the dose and recruitment of the next group of patients which marks a
positive progression in the trial.
Rationale for the Placing
In the Company's AIM admission document which was issued on 14 July 2010, the
Directors stated that, following the raising of £2.54 million (before costs)
earlier in 2010, they believed that the proceeds, together with the existing
funds available to the Group and future anticipated revenues, would be
sufficient to allow completion of the Phase I/IIa clinical trial of SCIB1;
however, as mentioned in the AGM Statement on 14 December 2010 and in the
interim results announced on 31 January 2011, the delay experienced in patient
recruitment has had resource implications for Scancell because the clinical
trial is now forecast to take longer than originally expected and it is
unlikely that the Company will be able to generate revenues from a commercial
deal on the ImmunoBody® technology until after the Phase I clinical trial has
been completed and reported. This is now expected in the first quarter of 2012.
Due to the delay in patient recruitment and without revenues from a commercial
deal the Company is unlikely to have sufficient working capital to be able to
complete the Phase I clinical trial of SCIB1. The Company is therefore
proposing to raise £1.73 million by way of the conditional placing of the
Placing Shares at the Placing Price. The net proceeds of the Placing will be
used to fund the working capital of the Group and the Directors believe that
the funds raised, together with the existing cash resources, will be sufficient
to enable the completion of the Phase I clinical trial for SCIB1.
After the Phase I clinical trial has been completed, the Company will seek to
generate revenues from a commercial deal on the ImmunoBody® technology. However
if the Company is unable to generate revenues from a commercial agreement or if
it takes longer than expected to reach a commercial agreement on the technology
then a further fundraising may be required in mid 2012 in order to provide
sufficient working capital to enable completion of the Phase II clinical trial
for SCIB1.
The Board is of the opinion that, without completion of the Placing, the
working capital currently available to Scancell may not be sufficient for its
requirements for the next 12 months following the date of this announcement.
3. Current Trading and Prospects
The audited results of the Group for the year ended 30 April 2011, which were
announced earlier today, reported revenue of £nil (2010: £nil) and a loss after
tax for the period of £1,649,000 (2010: £1,737,000). The reduction in the loss
was due to the slower than anticipated recruitment of patients for the clinical
trials, which have resulted in milestone payments to the CRO, which runs the
trials, being delayed. The loss per share for the period amounted to 10.4p
(2010: 16.2p). As at 30 April 2011 the Group had net assets of £4,636,000 (30
April 2010: £6,048,000). The Group had no external borrowings and cash reserves
at 30 April 2011 of £1,111,000 (30 April 2010: £2,380,000). Immediately
following the Placing the Company will have cash resources of approximately £
2.21 million.
4. Details of the Subdivision
The Directors propose to subdivide each Existing Ordinary Share of 1p each into
10 Ordinary Shares of 0.1p each. The Directors believe that the Subdivision
will facilitate the enhancement of liquidity in the Ordinary Shares. The
Subdivision requires the passing of a resolution by Shareholders and
accordingly Resolution 1 will be proposed, as an ordinary resolution.
A CREST Shareholder will have their CREST account credited with the Ordinary
Shares following their admission to AIM, which is expected to be 8.00 a.m. on
26 July 2011. Certificated Shareholders will be issued with new share
certificates and existing certificates will become invalid from 8.00 a.m. on 26
July 2011.
If Resolution 1 for the Subdivision is passed, the share capital of the Company
(prior to the allotment of the Placing Shares) will comprise 159,517,900
Ordinary Shares. The Subdivision will not affect the rights attaching to the
Existing Ordinary Shares, other than to alter their nominal value and, in
particular, will not affect the voting rights of the holders of Existing
Ordinary Shares. The Subdivision will be made by reference to holdings of
existing ordinary shares on the register as at the close of business on 25 July
2011 ("Record Date").
As all Existing Ordinary Shares are being subdivided, each shareholder's
percentage holding in the issued share capital of the Company immediately
before and after the implementation of the Subdivision (but prior to the
allotment of the Placing Shares) will remain unchanged. Shares to be issued
under existing options will reflect the Subdivision. The rights attaching to
the Ordinary Shares shall be identical to the rights attaching to the Existing
Ordinary Shares.
5. The Placing
The Company is proposing to raise £1.73 million, before expenses, by way of the
conditional placing of the Placing Shares at the Placing Price. The Placing is
conditional upon, inter alia, (i) the passing of the Resolutions; and (ii)
Admission. The Placing has not been underwritten. The Placing Shares will, when
issued, rank pari passu in all respects with the Existing Ordinary Shares
following the Subdivision, including the right to receive all dividends and
other distributions declared, made or paid after Admission.
Application will be made for the Placing Shares to be admitted to trading on
AIM. It is expected that Admission will become effective and that dealings will
commence on 26 July 2011. It is expected that the Placing Shares will be
delivered into CREST on 26 July 2011 or, as applicable, that share certificates
for the Placing Shares will be dispatched by no later than 9 August 2011.
In consultation with Zeus Capital and XCAP, the Board has held meetings with a
number of prospective new investors and with certain of the Company's largest
shareholders, and has concluded that, in light of those discussions and current
market conditions, the proposed Placing represents the best financing option
currently available to the Company. The Board decided not to make the Placing
open to all the Shareholders on a pre-emptive basis as it felt that to do so
would have resulted in the Company incurring additional expense.
The Company has received assurances from HM Revenue & Customs that subject to
the fulfilment of the relevant conditions the Placing Shares should qualify for
EIS and VCT relief. The availability of tax relief will depend, inter alia,
upon the investor and the Company continuing to satisfy various qualifying
conditions. The Directors are mindful of these conditions and do not intend
that the Company's activities should cause them to cease to be complied with;
however, it is the Directors' intention to seek a trade sale at a suitable
stage, probably following conclusion of Phase II clinical trials in respect of
SCIB1, if it is advantageous to shareholders generally. The Phase II clinical
trial is expected to be completed in 2013. Therefore a trade sale could
potentially occur within a three year period from the date of the issue of the
Placing Shares.
The Company cannot guarantee to conduct its activities in such a way as to
maintain its status as a qualifying EIS or VCT investment. Investors
considering taking advantage of EIS relief or making a qualifying VCT
investment are recommended to seek their own professional advice in order that
they may fully understand how the relief legislation may apply in their
individual circumstances. Any Shareholder who is in any doubt as to his
taxation position under the EIS and VCT legislation, or who is subject to tax
in a jurisdiction other than the UK, should consult an appropriate professional
adviser.
6. Share Issuance Authorities
The Directors currently have existing authorities under section 551 and
sections 570 and 573 of the 2006 Act which were obtained at the Company's
Annual General Meeting held on 14 December 2010. However, these would be
insufficient to enable the Company to allot and issue the Placing Shares.
Accordingly, in order for the Company to allot and issue the Placing Shares the
Company needs Shareholders to grant the Board additional authority to issue
Ordinary Shares and to disapply statutory pre-emption rights which would
otherwise apply to the issue of the Placing Shares. The Company is therefore
asking Shareholders to increase the Directors' general authority to allot
securities and disapply pre-emption rights pursuant to section 551 of the 2006
Act and sections 570 and 573 of the 2006 Act, respectively. A summary of the
Resolutions is set out in paragraph 7 below.
7. General Meeting
Set out at the end of the Circular is a notice convening the General Meeting to
be held at the offices of Laytons Solicitors, Carmelite, 50 Victoria
Embankment, London EC4Y 0LS at 10.45 a.m. (or at such later time as immediately
following the conclusion of the Annual General Meeting of the Company convened
to he held at 10.30 a.m. that day) on 25 July 2011 at which the following
resolutions will be proposed for the following purposes:
1. an ordinary resolution to subdivide each Existing Ordinary Share, and any
to be issued ordinary shares in the Company, into 10 new Ordinary Shares;
2. an ordinary resolution to authorise the Directors to allot shares in the
Company up to an aggregate nominal amount of £34,575.41 pursuant to section
551 of the 2006 Act; and
3. a special resolution pursuant to sections 570 and 573 of the 2006 Act to
disapply the statutory pre-emption provisions under section 561(1) of the
2006 Act in relation to the shares authorised for allotment under
Resolution 2.
The authorities granted by resolutions 2 and 3 would be in addition to the
authorities proposed at the Company's 2011 Annual General Meeting and will
expire on 31 December 2011. The attention of Shareholders is also drawn to the
voting intentions of the Directors as set out in the paragraph entitled
"Recommendation" below.
8. Risk Factors
There are a number of potential risks involved in investing in specialist
biotechnology companies such as Scancell, including, but not limited to,
clinical, regulatory, manufacturing, commercial and intellectual property risks
and the requirement to raise additional finance. These risks and additional
risks and uncertainties not currently known to the Directors, or that the
Directors currently deem immaterial, could potentially have an adverse effect
on the Group's business, financial condition and results of operations.
Investors are advised to consult an independent financial adviser authorised
under the Financial Services and Markets Act 2000 who specialises in advising
on the acquisition of shares and other securities before making a decision to
invest in the Company.
9. Recommendation
The Directors recommend that Shareholders vote in favour of the Resolutions as
they intend to do in respect of their own shareholdings, amounting in aggregate
to 2,942,892 Existing Ordinary Shares (representing approximately 18.45 per
cent. of the Existing Share Capital).
DEFINITIONS
The following definitions shall apply throughout this announcement unless the
context otherwise requires:
"2006 Act" the Companies Act 2006;
"Admission" the admission of the Placing Shares to trading
on AIM;
"AIM" the AIM market operated by the London Stock
Exchange;
"AIM Rules" means the Rules and Guidance notes for AIM
companies and their nominated advisers issued
by the London Stock Exchange from time to time
relating to AIM traded securities and the
operation of AIM;
"Circular" the document dated 30 June 2011, including the
notice of GM, addressed to the Shareholders;
"Completion" completion of the Proposals;
"CREST" the relevant system (as defined in the
Uncertificated Securities Regulations 2001 (the
"Regulations")) in respect of which Euroclear
is the Operator (as defined in the Regulations)
and in accordance with which securities may be
held and transferred in uncertificated form;
"Directors" or "Board" the directors of the Company;
"EIS" Enterprise Investment Scheme;
"Enlarged Share Capital" the entire issued share capital of the Company
following the implementation of the
Subdivision, Admission and completion of the
Placing;
"Existing Ordinary Shares" the 15,951,790 ordinary shares of 1p each in
issue at the date of this announcement prior to
implementation of the Subdivision;
"Existing Share Capital" the entire issued share capital of the Company
as at the date of this announcement prior to
implementation of the Subdivision;
"GM" or "General Meeting" the general meeting of the Company convened for
25 July 2011 at 10.45 a.m. (or at such time as
immediately following the conclusion of the
Annual General Meeting of the Company convened
to be held at 10.30 a.m. that day) at Laytons
Solicitors, Carmelite, 50 Victoria Embankment,
London EC4Y 0LS, or any adjournment thereof;
"Group" the Company and its subsidiaries;
"Ordinary Shares" ordinary shares of 0.1p each in the capital of
the Company following the implementation of the
Subdivision;
"Placing" the conditional placing of the Placing Shares
at the Placing Price pursuant to the Placing
Agreement;
"Placing Agreement" the conditional agreement dated 30 June 2011
between (1) Zeus Capital, (2) XCAP Securities
plc and (3) the Company relating to the
Placing;
"Placing Price" 5 pence per Placing Share;
"Placing Shares" 34,575,410 Ordinary Shares proposed to be
issued
pursuant to the Placing;
"Proposals" the Subdivision, the Placing and Admission;
"Resolutions" the resolutions to be proposed at the General
Meeting;
"RIS" Regulatory Information Service;
"Shareholders" the persons who are registered as holders of
Existing Ordinary Shares as at the date of this
announcement;
"Subdivision" the subdivision of the Company's share capital,
being the subdivision of each Existing Ordinary
Share into 10 Ordinary Shares;
"VCT" Venture Capital Trust;
"XCAP" XCAP Securities plc (registered in England and
Wales under number 06920660);
"Zeus Capital" Zeus Capital Limited (registered in England and
Wales
under number 4417845).