Holding(s) in Company

Advanced Medical Solutions Grp PLC
28 November 2007


TR-1: Notifications of Major Interests in Shares


                                                                        

1. Identity of the issuer or the underlying issuer of existing
shares to which voting rights are attached:

                                                                        Advanced Medical Solutions
2. Reason for notification (yes/no)
                                                                               

An acquisition or disposal of voting rights
                                                                               Yes

An acquisition or disposal of financial instruments which may result in the acquisition of
shares already issued to which voting rights are attached


An event changing the breakdown of voting rights


Other (please specify):
                                                            

3. Full name of person(s) subject to notification
obligation:
                                                            Newton Investment Management Limited

4. Full name of shareholder(s) (if different from
3):
                                                                          

5. Date of transaction (and date on which the
threshold is crossed or reached if different):                            27/11/07
                                                                          

6. Date on which issuer notified:                                         28/11/07
                                                                

7. Threshold(s) that is/are crossed or reached:                 Decrease from 6.41% to 5.90%

8: Notified Details                                                Sale of 730,000 shares

A: Voting rights attached to shares


Class/type of       Situation previous to    Resulting situation after the triggering transaction
shares              the triggering
                    transaction
If possible use     Number of    Number of   Number of   Number of voting rights  Percentage of voting
ISIN code           shares       voting      shares                               rights
                                 rights

                                                         Direct      Indirect     Direct      Indirect
  Ordinary shares    9,177,657    9,177,657      N/A         N/A      8,447,657      N/A       5.90%
   GB0004536594


B: Financial Instruments


Resulting situation after the triggering transaction


Type of financial    Expiration date      Exercise/ conversion No. of voting rights  Percentage of voting
instrument                                period/date          that may be acquired  rights
                                                               (if the instrument
                                                               exercised/converted)





Total (A+B)


Number of voting rights                             Percentage of voting rights

      8,447,657                                             5.90%


9. Chain of controlled undertakings through which the voting rights and /or the financial instruments are effectively
held, if applicable:
Newton Investment Management Limited hold these shares as a discretionary Investment Manager.




Proxy Voting:


10. Name of proxy holder:                                                    N/A


11. Number of voting rights proxy holder will cease                          N/A
to hold:

12. Date on which proxy holder will cease to hold                            N/A
voting rights:


13. Additional information:


14 Contact name:                                       Mary Tavener


15. Contact telephone name:                            [phone]






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