Holding(s) in Company

Advanced Medical Solutions Grp PLC
31 January 2005


Advanced Medical Solutions Group plc ('AMS' or the 'Company')

The Company received notification on 31 January 2005 stating that Close Brothers
Group plc ('Close Brothers') no longer has a notifiable interest in the ordinary
shares of 5p each ('Ordinary Shares') in AMS following the sale of 7,334,513
Ordinary Shares on 21 January 2005.

Close Brothers' interest in the issued share capital of AMS has been reduced to
12,372,938, representing 8.71 per cent. of the issued share capital of the
Company.

These interests are non-beneficial to Close Brothers Group plc and arise by
virtue of the discretionary management of the above Ordinary Shares under
written agreements between the beneficial owners of the Ordinary Shares and
Close Investment Limited, Close Venture Management Limited, Close Finsbury Asset
Management and Reabourne Technology Investment Management Limited, which are
subsidiaries of Close Brothers Group plc.


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