Interest in Major Shares

Alliance Pharma PLC
21 March 2006







Immediate Release                                                  21 March 2006



                              Alliance Pharma Plc

                    Notification of Major Interests in Shares

On 17 March 2006, the company was notified by Fidelity Investment International,
that two of its nominee accounts have a notifiable interest in 8,799,900 shares,
representing 5.97% of the issued share capital of Alliance Pharma.

                                     -ENDS-


For further information:

Alliance Pharma plc                                        + 44 (0) 1249 466966
John Dawson, Chief Executive
Maddy Scott, Finance Director
www.alliancepharma.co.uk

Numis Securities                                           + 44 (0) 20 7776 1500
David Poutney

Buchanan Communications                                    + 44 (0) 20 7466 5000
Mark Court/Lisa Baderoon/Rebecca Skye Dietrich






                      This information is provided by RNS
            The company news service from the London Stock Exchange