Major Interest in Shares

Alliance Pharma PLC
22 February 2008


For Immediate Release                                          21 February 2008

                              ALLIANCE PHARMA PLC


             TR - 1: NOTIFICATION OF MAJOR INTERESTS IN SHARES


1.  Identity of the issuer or the underlying issuer of existing shares to
    which voting rights are attached:

Alliance Pharma plc

2. Reason for the notification (please tick the appropriate box or boxes):

An acquisition or disposal of voting rights

3. Full name of person(s) subject to the notification obligation:

Aviva plc & its subsidiaries

4. Full name of shareholder(s) (if different from 3.)

Registered Holder:

CUIM Nominee Limited 2,700,000*

* denotes direct interest

BNP Paribas - London 4,450,000

Chase Nominees Limited 11,025,755

5. Date of the transaction and date on which the threshold is crossed or
   reached:

20 February 2008

6. Date on which issuer notified:

21 February 2008

7. Threshold(s) that is/are crossed or reached:

10% to 11% Change at Combined Interest Level

8. Notified details:

3.11

A: Voting rights attached to shares

+--------------+----------------------+--------------------------------------------------+
|Class/type of |Situation previous to |Resulting situation after the triggering          |
|shares        |the Triggering        |transaction                                       |
|              |transaction           |                                                  |
|if possible   +----------+-----------+---------+----------------------+-----------------+
|using the ISIN|Number of |Number of  |Number of|Number of voting      |% of voting      |
|CODE          |Shares    |Voting     |shares   |rights                |rights           |
|              |          |Rights     +---------+----------+-----------+--------+--------+
|              |          |           |Direct   |Direct    |Indirect   |Direct  |Indirect|
+--------------+----------+-----------+---------+----------+-----------+--------+--------+
|GB0031030819  |17,175,755|17,175,755 |2,700,000|2,700,000 |15,475,755 |1.67%   |9.55%   |
+--------------+----------+-----------+---------+----------+-----------+--------+--------+

Total (A+B)

Number of voting rights                % of voting rights
18,175,755                             11.22%

9.  Chain of controlled undertakings through which the voting rights and/or the
    financial instruments are effectively held, if applicable

n/a

Proxy Voting:

10. Name of the proxy holder:

n/a

11. Number of voting rights proxy holder will cease to hold:

n/a

12. Date on which proxy holder will cease to hold voting rights:

n/a

13. Additional information:

Figures are based on a total number of voting rights of 162,061,774

For further information:

Alliance Pharma plc                                   + 44 (0) 1249 466966

John Dawson, Chief Executive
Richard Wright, Finance Director
www.alliancepharma.co.uk

Buchanan Communications                              + 44 (0) 20 7466 5000

Mark Court / Rebecca Skye Dietrich

Numis Securities                                     + 44 (0) 20 7260 1000
David Poutney / Michael Meade




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