Major Interest in Shares

Alliance Pharma PLC
31 August 2007


For Immediate Release                                             31 August 2007

                                        
                              Alliance Pharma Plc
                                        
                    Notification of Major Interests in Shares

Alliance Pharma plc (AIM: APH), the speciality pharmaceutical company, was
notified  on 30 August, 2007 that RAB Special Situations (Master) Fund Ltd,
through Credit  Suisse Client Nominees (UK) Ltd are now interested in 19,943,399
Ordinary  Shares of Alliance Capital representing 12.31% of the issued share
capital of the  Company.

                                     -ENDS-

For further information:

Alliance Pharma plc                                          + 44 (0) 1249466966
                                                                          
John Dawson, Chief Executive

Richard Wright, Finance Director

www.alliancepharma.co.uk

Numis Securities                                            + 44 (0) 20 72601000
                                                                            
David Poutney / Michael Meade

Buchanan Communications                                     + 44 (0) 207466 5000
                                                                      
Mark Court /Rebecca Skye Dietrich

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