Preliminary Results

Alliance Pharma PLC 12 May 2005 For Immediate Release 12 May 2005 ALLIANCE PHARMA PLC ('Alliance Pharma' or 'the Company') Preliminary Results for the year ended 28 February 2005 Alliance Pharma plc (AIM: APH), an emerging speciality pharmaceutical company, is pleased to announce its preliminary results for the year ended 28 February 2005. These are the Company's first full year results as a listed company, following the Company's admission to AIM in December 2003. Financial Highlights • Turnover increased 13% to £11.8 million (2004: £10.4m) - the full year impact of two product acquisitions in November 2004, Periostat(R) and Forceval(R), would show an annualised turnover of £15m • Gross margin improved to 52.4% (2004: 48.4%) • Adjusted EBAT (earnings before exceptional items, amortisation and tax) of £0.645 million (2004: £1.21m) - the decrease largely reflecting the investment in infrastructure and the marketing expenditure associated with current and pipeline products • Profit before tax of £0.418 million (2004: loss of £2.15m) • Operating cashflow remains strong at £1.59 million (2004: £2.11m) • Adjusted earnings per share 0.52p (2004: 1.18p) • Basic earnings per share 0.34p (2004: loss per share of 2.44p) Operational Highlights • Continued strong sales growth of Symmetrel(R)and Nu-Seals(R) • Acquisition of Periostat and Forceval in November 2004 • Regulatory approval anticipated imminently to begin clinical trials of Posidorm(TM), melatonin in sleep disorders • Start of Phase III clinical trials in January 2005 of APL 202 misoprostol for the induction of labour • Launch of International division to drive overseas sales through out-licensing and distributors • Co-promotion agreement signed with OralDent Ltd for the UK marketing and distribution of Periostat(R), a prescription medicine for the treatment of the severe gum disease periodontitis Commenting on the results, John Dawson, Alliance Pharma's Chief Executive, said: 'These results underline the robustness of Alliance Pharma's business model, in which the cashflow from our marketed products supports the development of our clinical pipeline. We will shortly commence the trial programme leading to registration for our product Posidorm(TM) for sleep disorders, which seeks to address a market that is currently at £0.5bn but which is expected to treble in the next decade.' For further information: Alliance Pharma plc + 44 (0) 1249 466966 John Dawson, Chief Executive Maddy Scott, Finance Director www.alliancepharma.co.uk Buchanan Communications + 44 (0) 20 7466 5000 Mark Court/Lisa Baderoon/Rebecca Skye Dietrich Notes to editors About Alliance Pharma Alliance Pharma, founded in 1996, is an AIM listed emerging speciality pharmaceutical company based in Chippenham, Wiltshire, UK. The company has a strong track record of acquiring the rights to established niche brands and owns, or shares, the rights to 30 branded pharmaceutical products and continues to explore opportunities to expand the range. Alliance Pharma's products are prescribed in the treatment of a wide range of conditions and include brands used in periodontitis, a gum disease, the prevention of heart disease, in Parkinson's disease, in nutrition, in nasal infections, in the treatment of dermatological conditions and in childbirth. Alliance Pharma's sales are mainly prescription driven. Its products are distributed to hospitals directly and to pharmaceutical wholesalers which service both hospital and retail pharmacies with their prescription requirements. Alliance Pharma is also developing novel products for sleep disorders and the induction of labour. Alliance Pharma joined the AIM market of the London Stock Exchange in December 2003 and trades under the symbol APH. Chairman's Statement This is Alliance Pharma's first full year's accounts as a publicly listed company and show a purposeful continuation of the broad strategy we outlined at the time of our obtaining a listing, namely: • Obtaining turnover, margin and cashflow from a portfolio of mature branded pharmaceutical products and investing further in the marketing and promotion of those products judged to have real potential for growth • Taking our two current clinical development projects towards commercialisation and • A continuing evaluation of opportunities arising from the wider rationalisation of the pharmaceutical industry, with a view to acquiring additional branded products and/or development opportunities that fall within our chosen area of expertise and investment criteria The year's results show our moving forward in all aspects of the strategy. During the year to February 2005, sales from our existing portfolio grew some 7%, on a like for like basis, with good gross margin improvement mainly arising from our promoted brands Nu-Seals(R) and Symmetrel(R). During the year we acquired Forceval(R), a prescription multi-vitamin, and Periostat(R), a treatment for periodontitis. Both contributed to the overall sales and gross margin increase during the year but, more importantly, looking to the future, offer good potential for further growth in the UK and in overseas territories where we have also acquired distribution rights. Further, through the acquisition of Periostat we have entered the substantial dental market and have already taken additional steps to widen our involvement in it. The work programme for our two key clinical development projects - Posidorm(TM), melatonin for sleep disorders, and APL 202, misoprostrol for labour induction - has begun in earnest. The trials programmes have been established and necessary pre-marketing expenditure incurred, all within a carefully planned and costed framework. When completed these projects have the potential to transform the business. Trading profit, at £0.645m (before exceptional items) was lower than last year but this was expected as it largely resulted from the continuing marketing expenditure on our promoted brands and the pre-marketing expenditure for our development projects. Both these categories of cost are, in reality, an investment in the future. Additionally the 7% price reduction under the 2005 PPRS settlement cost us £155,000 from December 2004 to February 2005. Taking a wider look at our financial position, the benefits of our AIM listing are clear. During the year we were able to raise some £4.2m through the issue of new shares, to be used towards the cost of the Forceval and Periostat acquisitions with the balance of the consideration being provided by a new loan facility. Having wider potential access to capital has enabled us to continue work on our development projects. The year has also seen necessary changes in our organisation. The team led by John Dawson has grown from 13 to 21, which, while still relatively small, can operate in a more structured way with clear lines of responsibility and profit accountability on a business unit basis. All in all, this has been a year of solid achievement on which we will continue to build for the future. Our brand and product development projects have clearly established programmes for the coming year, while we continue to be alert to identify new opportunities. Based on the experience of the early months of the current year, trading results continue to be satisfactory. Michael R B Gatenby Chairman 12 May 2005 Chief Executive's Review Strategic Overview In the year ended February 2005, tremendous progress on the growth of Alliance has been made on many fronts. We have moved our two development projects - Posidorm(TM), melatonin for sleep disorders, and APL 202, misoprostol for induction of labour - further down the path towards marketing; we have acquired a major growth opportunity in Periostat for periodontitis; we have acquired a significant and respected cash-generative brand in the prescription multivitamin, Forceval; we have made considerable development to the operational team; and via the acquisitions of Periostat and Forceval we now have international opportunities beyond our historical territories of the UK and Ireland. Progress in 2004 Sales development Sales for the year grew by £1.4m or 13.5%; 6.8% being like-for-like, principally from Nu-Seals(R) and Symmetrel(R), and 6.7% through the acquisitions of Periostat(R) and Forceval(R) in November 2004. UK sales were affected by the 7% PPRS price decrease, which became effective from January 2005. Although this anticipated price decrease was significant, it does mean that in the UK, for branded prescription medicines, there is price stability going forward for five years. Nu-Seals, our low-dose enteric-coated aspirin for the prevention of heart attacks and strokes, continues to grow well (17%) in Ireland, where there is much emphasis on reducing cardiovascular disease. Symmetrel, our product for treating dyskinesias, which are large involuntary movements associated with Parkinson's disease, experienced growth of 18% as our UK hospital field force established itself. In the other area where we have been placing promotional effort, the group of four dermatology brands that we acquired from Dermapharm Ltd in February 2004, growth was 15%. Financial Performance As had been forecast, profitability reduced as we invested in the UK hospital field force and in pre-marketing activities for our two development projects. Before exceptional items, amortisation and tax, profits were £0.645m, compared with £1.210m in the prior year (a reconciliation of these numbers is in the Financial Review). Following our reassessment of the useful economic lives of our intangible fixed assets to indefinite, the brands we have acquired over the past six years were subjected to a full impairment review. This review concluded that the value of these intangible assets has not been impaired since acquisition and supports our long-standing practice of judging our trading profit before amortisation. Going forward our previous practice of amortising our brands over 20 years will be replaced by an annual impairment review. Development pipeline Our largest development opportunity is Posidorm(TM) for sleep disorders. Melatonin is the body's natural hormone for regulating the sleep/wake cycle. When given therapeutically it can alleviate several sleep disorders connected with melatonin imbalance. These are found in the elderly; in patients with neurological damage; in the blind; in shiftworkers; and in travelling across time-zones. Although not yet registered, UK prescribing of melatonin on a named patient basis supplied by other companies is estimated to be worth between £5m and £6m. We are developing Posidorm(TM) for registration across the EU, initially in the indications of sleep disorders associated with shiftworking and in the elderly, where market research has shown that doctors recognise sleep disorders in the elderly as a major problem and would welcome the opportunity to wean their patients off the long-term usage of existing hypnotic drugs. Overall the market for products for sleep disorders across the EU is currently worth £500m (IMS data) and is forecast to treble in the next decade (ESPICOM research). Hypothetically, if every patient in the EU suffering from the two sleep disorders addressed by our clinical developments were to receive melatonin therapy, the market would be in excess of £2bn. We intend to expand our own sales forces in the UK and Ireland for the launch and marketing of Posidorm(TM). On the Continent we intend to commercialise the opportunity via out-licensing agreements. We have successfully developed an advanced, surge-sustained tablet formulation that has performed well in the pharmacokinetic trials. Approvals are expected to be received imminently for the commencement of the clinical trials programme, which leads to product registration. The trials will start during this current quarter of Q2 2005 and a registration application is expected during the second half of 2006. Since melatonin has not been previously registered in the EU, we anticipate that we shall gain data exclusivity, thus preventing generic companies from cross-referencing our data for a period of ten years. Our second development is APL 202, a vaginal tablet of misoprostol for the induction of labour, to be used when pregnancy has progressed beyond its term. The use of misoprostol for the induction of labour has been well researched over the past decade and is well known as a treatment option to obstetricians. Several clinical trials have shown misoprostol to yield more reliable results than the current market leader in this area. However there is no suitable form of misoprostol on the market for this indication and indeed in 2002 the Royal College of Obstetricians and Gynaecologists called for an obstetric form to be developed. Across the EU it is estimated that there are over 700,000 induced births per year and the existing market for induction agents is £13m per annum. We intend to market APL 202 via our existing field forces in the UK and Ireland and to seek marketing and distribution partners on the Continent. Our clinical trials programme started in January 2005 and we expect to be submitting for registration around the end of this year. Acquisitions Last November we made two important brand acquisitions, namely, Periostat (doxycycline 20mg) for periodontitis, which we acquired from CollaGenex Inc for $3.3m, and Forceval, a prescription multi-vitamin/multi-mineral product for clinical malnutrition, which we acquired from the Administrators of Unigreg Ltd for £7m. Periodontitis is a severe form of gum disease in which openings or pockets develop between the tooth and the gum, leading to abscesses, tooth sensitivity, tooth mobility and ultimately tooth loss. It is estimated to affect 11% of the adult population in the UK. Whilst the disease process starts off as a background infection, it is exacerbated by the body producing an excess of the enzyme collagenase, which destroys the supporting structures which hold the affected tooth in place. Left unchecked, periodontitis often leads to the loss of otherwise healthy teeth. Traditional treatment involves extensive cleaning of plaque and debris by an intensive procedure known as scaling and root planing, sometimes in conjunction with short-term antibiotics, and coaching the patient to improve his or her oral hygiene. Periostat enhances traditional treatment by suppressing the collagenase enzyme that is destroying the dental support structures, thus facilitating the closing of the gum pockets and accelerating the healing process. Periostat was introduced into the UK dental market three years ago, but has received minimal promotion and its UK sales are just under £300,000. However, in the US, where CollaGenex has marketed the product effectively, sales have reached $45m after five years. Following our co-promotion agreement with OralDent Ltd, from May 2005 we now have an effective dental marketing operation in the UK from which to develop the brand. Additionally we have, as territories to develop, the rest of the enlarged EU plus Switzerland, Israel, Australia, New Zealand and South Africa. Through the acquisition of Periostat, we feel we have secured a very significant growth opportunity. The acquisition of Forceval, and other minor brands from Unigreg Ltd, with sales of £2.8m, adds to the portfolio an established, profitable brand which, in terms of sales and profits, will rank second to Nu-Seals. The international sales of Forceval, which amount to around £0.8m, arise from only ten territories. We have acquired the rights to all territories apart from China and therefore, working via new distributors in new territories, some growth in international sales can be expected. Organisation In December 2004, our UK hospital sales force, which was set up in December 2003 on an out-sourced basis, was brought onto our payroll, having established itself as an effective operation. It is currently promoting Symmetrel to neurologists and care-of-the-elderly physicians and our dermatology range to dermatologists. During the coming year it will start to establish relationships with obstetricians in preparation for the launch of APL 202 misoprostol in 2006. During the year we have also made measured investments in infrastructure to drive the future growth of the business. We have added depth to our Scientific Affairs area in order to manage the development of the new products Posidorm(TM) and APL 202. Following the acquisition of Periostat, we have recruited an experienced dental industry executive to head up the new Dental Products business unit and also an experienced international manager to drive the international opportunities of Periostat and Forceval. To optimise the management of our expanded portfolio and to prepare for the introductions of Posidorm(TM) and APL 202, during the year we instituted a business unit structure, placing responsibility for operational profitability with the business unit manager. Looking Forward We can expect continued incremental growth from Nu-Seals, Symmetrel and our dermatology range. The launch of APL 202 for induction of labour, anticipated in 2006, will bring moderate, but nevertheless significant, growth. However the real opportunities for transformational growth are from Periostat in periodontitis and Posidorm(TM) in sleep disorders, following its expected introduction in 2007. With the management now in place and a co-promotional partner now on board, growth in Periostat is expected to commence in the second half of this year. For Posidorm(TM), aside from the obvious completion of the development programme, the key factors affecting success will be concerned with the quality of our pre-marketing and our selection of the right marketing partner for the Continent. Resources and effort going into these factors are of a top priority. We will continue to build the financial base of the company by further acquisitions of cash-generative brands when the right opportunities arise. Our track record of eight transactions in six years demonstrates our ability to find and execute these deals; our recent impairment review showing zero impairment of the assets acquired demonstrates our ability to screen and select the best of the opportunities on offer. The climate for portfolio rationalisation amongst big pharma continues to be favourable and therefore we anticipate that further good opportunities will present themselves. Our practice of leveraging the fresh equity going into each transaction with an appropriate amount of debt optimises the longer-term shareholder return. Overall trading so far this year is in line with the expectation set following our acquisition of Periostat and Forceval in November 2004. Finally we look forward to the future with the increased confidence that is drawn from the quality of the team we are building. The high quality and big pharma backgrounds of our senior team have often been commented upon. By selective recruitment and development we are now putting the necessary depth into the organisation. John Dawson Chief Executive 12 May 2005 Financial Review Key Figures 2005 2004 % Increase Turnover £11.826m £10.416m 13.5% Gross Profit £6.201m £5.039m Gross Margin % 52.4% 48.4% Operating Expenses £3.930m £4.335m (10.3)% Interest charges (excl other finance chgs) £1.661m £1.502m 10.6% Adjusted EBAT (earnings before amortisation, tax, £0.645m £1.210m (46.7)% exceptional project costs and finance charges - as reconciled below) Profit/(loss) before tax £0.418m £(2.153m) - Net assets £6.824m £2.224m - Basic earnings per share 0.34p (2.44p) 113.9% Adjusted earnings per share 0.52p 1.18p (55.9)% Turnover The turnover for the year increased 13.5% to £11.8m from £10.4m. Of this 6.8% was a like for like increase on the previous year with the remaining 6.7% being due to the acquisition of the product licences for Periostat and Forceval in November 2004. The impact of these acquisitions was an increase in turnover of £0.7m and gross margin of 1.3%. The full year impact of these acquisitions would show an annualised turnover of £15.0m. Gross Profit The 4.0% improvement in gross margin from 48.4% to 52.4% was partly due to the full year impact of the improvements in cost of goods made on the acquisition of Nu-Seals in 2002 and partly due to the acquisitions of Periostat and Forceval. The running rate of gross margin would be 54.5% for a full year impact of the acquisitions. Operating Expenses During the year a thorough review of the useful economic lives of all intangible assets was made, the result being that this was determined to be indefinite and as such no amortisation has been charged during the year. Therefore the prior year operating expenses figure should be restated to remove amortisation of £1.750m, (brand amortisation accounted for £0.907m whilst reverse takeover goodwill was £0.843m) to show a like for like comparison of £2.585m. There was significant investment in the future growth of the company made through the operating expenses, of which an additional £0.800m was due to sales and marketing expenses for the promotions of our UK hospital products and the early marketing activities for the development of APL202 misoprostol and APL510 melatonin. The remaining increase is due to the investment in the infrastructure of the company to support the activities to drive the future growth. 2005 2004 % Increase Operating Expenses £3.930m £4.335m (9.6)% Project costs in relation to aborted acquisition £0.110m - Amortisation - £1.750m Operating Expenses (excl amortisation) £3.820m £2.585m 52.1% Finance Costs The increase in ongoing interest payable from £1.502m to £1.661m in the financial year reflected the full year impact of the interest payments on the convertible loan stock, and the additional debt provided by Bank of Scotland in November 2004 for the acquisition of Forceval. The other finance charges reflects the effect of the movement in the exchange rate on the euro denominated loan of £0.118m and £1.345m shown in the prior year being one-off costs associated with the AIM listing. 2005 2004 % Increase Interest charges (excl other finance charges and £1.661m £1.502m 10.6% amortised finance issue costs) Amortised finance issue costs £0.074m £0.009m Total finance costs before exceptional items £1.735m £1.511m Other finance charges £0.118m £1.345m - Profit Before Tax A profit before tax of £0.418m has been achieved in the year, an improvement on the prior year loss of £2.153m. Adjusting the profit before tax to exclude the exceptional items of £0.227m shows a trading profit of £0.645m. The exceptional items are partly due (£0.118m) to the revaluation of the Euro denominated loan as required by SSAP20 and the project costs associated with an aborted acquisition attempt during the year. The prior year exceptional items relate to the reverse takeover transaction during the prior year as shown below: 2005 2004 Profit/(loss) on ordinary activities before taxation £0.418m £(2.152)m Amortisation of intangible assets - £0.907m Exceptional Items: Costs associated with Peerless Technology prior to the reverse - £0.258m takeover Amortisation of reverse takeover goodwill - £0.843m Debt redemption premia - £1.185m Exceptional project costs, finance charges and finance issue £0.110m £0.169m costs Foreign exchange movement on Euro denominated load £0.118m - Adjusted trading profit £0.645m £1.210m This drop in trading profit had been previously forecast as we planned our investment in our UK marketing capability and preparations connected with our launch products. Earnings per share The basic earnings per share of 0.34p is an improvement on the prior year position of a loss per share of 2.44p. However this was heavily distorted by one-off charges and tax credits recognised in the year. An adjusted EPS figure of 0.52p (1.18p 2004) reflects the investments made during the year in marketing and infrastructure expenses and removes exceptional items, amortisation, other finance charges and deferred tax. Cashflow The cash inflow from operating activities was £1.6m. During the year £4.2m was raised from the issue of shares and was used to acquire Periostat for $3.3m plus costs and part of the consideration for Forceval. The remainder of the total consideration for Forceval of £7.0m plus costs, was funded by way of £6.5m debt from Bank of Scotland. The reduction in the net operating cashflow is as a result of the investment in working capital stemming from the acquisitions. Net Assets The issue of shares to fund the acquisitions is the main contributor to the increase in Net Assets to £6.824m (2004: £2.224m). A further £0.858m was invested in the development of APL202 misoprostol and Posidorm(TM), adding to the prior year spend of £0.487m, bringing the total to £1.346m. These costs have been capitalised having met the criteria set by the current UK accounting standard (SSAP13). Each project has been re-examined to ensure that it has technical feasibility and has ultimate commercial viability. Net Debt The net debt position increased to £22.6m (2004: £16.0m) , including the Convertible Loan Stock at £7.5m, the increase being principally due to the funding from Bank of Scotland for the Forceval acquisition. Of the total debt, 89.4% is subject to long term fixed interest rates resulting from the Convertible Loan Stock interest being fixed and other interest rate swaps to reduce the interest rate exposure. The currency risk is reduced using a debt facility denominated in euros to match revenues arising in the Eurozone. Accounting Standards A working group has been established to assess the implications of International Accounting Standards and to prepare the restatement and confirm the accounting policies under the new regime. The decision has been made by the Directors of the company to adopt IFRS for the financial year commencing 1st March 2005 ahead of the required date for AIM listed companies. As such, additional unaudited information has been attached to the annual report to provide details of the impact on the opening balance sheet of the transition to IFRS. There were no significant adjustments. Madeleine Scott Finance Director 12 May 2005 Consolidated Profit & Loss Account for the year ended 28 February 2005 Note 2005 2005 2005 2004 Pre Total Total exceptional Exceptional £ £ £ £ Turnover 11,826,292 - 11,826,292 10,416,036 Cost of sales (5,624,857) - (5,624,857) (5,377,179) Gross profit 6,201,435 - 6,201,435 5,038,857 Operating expenses Administrative and marketing expenses 1 (3,820,470) (109,504) (3,929,974) (2,584,611) Amortisation of intangible assets - - - (1,750,245) (3,820,470) (109,504) (3,929,974) (4,334,856) Operating profit 2,380,965 (109,504) 2,271,461 704,001 Net interest payable and similar charges Net interest and similar charges 2 (1,661,487) - (1,661,487) (1,502,058) Other finance charges 2 (73,988) (117,727) (191,715) (1,354,449) (1,735,475) (117,727) (1,853,202) (2,856,507) Profit/(loss) on ordinary activities before 645,490 (227,231) 418,259 (2,152,506) taxation Tax on profit/(loss) on ordinary activities - - - 197,856 Profit/(loss) transferred to reserves 645,490 (227,231) 418,259 (1,954,650) Earnings/(loss) per share Basic (pence) 0.34 (2.44) Adjusted (pence) 0.52 1.18 Diluted (pence) 0.82 (2.44) Adjusted diluted (pence) 1.00 1.92 All of the activities of the company are classed as continuing. There were no recognised gains or losses other than the profit for the financial year. 1. Operating profit is stated: 2005 2004 £ £ After charging Auditors' remuneration - Group - audit services 29,500 18,500 - non-audit services 60,561 146,870 Auditors' remuneration - Company - audit services 8,500 8,000 - non-audit services 2,200 2,000 Amortisation of intangible assets - 907,074 Exceptional items 109,504 - - Project costs in relation to aborted acquisition - Amortisation of goodwill acquired in reverse takeover - 843,171 Depreciation of tangible assets 115,229 83,250 Operating lease rentals 42,816 40,839 After crediting 37,653 7,488 Profit on foreign exchange transactions With the exception of amortisation, all the above are included within operating expenses. 2. Net interest payable and other charges 2005 2004 £ £ (a) Net interest and similar charges (normal) On loans and overdrafts (1,820,209) (1,562,879) Interest receivable and similar income 161,726 63,669 Hire purchase interest (3,004) (2,848) (1,661,487) (1,502,058) (b) Other finance charges Foreign exchange movement on long term Euro denominated (117,727) - debt Amortised finance issue costs (73,988) (9,268) Costs of debt refinancing - (160,000) Loan redemption premiums - (1,185,181) (191,715) (1,354,449) (1,853,202) (2,854,507) Consolidated Balance Sheet at 28 February 2005 2005 2005 2004 2004 £ £ £ £ Fixed assets Intangible assets 28,095,015 17,987,603 Tangible assets 306,573 147,853 28,401,588 18,135,456 Current assets Stocks 2,469,363 1,739,516 Debtors 2,149,613 1,984,093 Cash at bank and in hand 1,367,271 4,579,197 5,986,247 8,302,806 Creditors: amounts falling due within one year (5,959,415) (5,462,778) Net current assets 26,832 2,840,028 Total assets less current liabilities 28,428,420 20,975,484 Creditors: amounts falling due after more than (21,604,114) (18,751,378) one year - including convertible debt 6,824,306 2,224,106 Capital and reserves Called up share capital 1,473,559 1,107,939 Share premium account 9,030,959 5,214,638 Other reserve (329,349) (329,349) Profit and loss account (3,350,863) (3,769,122) Shareholders' funds - equity interests 6,824,306 2,224,106 Consolidated Cash Flow Statement For the year ended 28 February 2005 2005 2004 Note £ £ Net cash inflow from operating activities 3 1,585,204 2,112,318 Returns on investments and servicing of finance Interest received 161,726 35,446 Interest paid and similar charges (1,820,209) (1,562,879) Loan redemption premiums paid - (1,185,181) Finance issue costs paid - (416,125) Other finance charges paid - (160,000) Hire purchase interest paid (3,004) (2,848) Net cash outflow for returns on investments and servicing of (1,661,487) (3,291,587) finance Taxation (12,747) - Capital expenditure Development costs capitalised (858,499) (487,110) Purchases of other intangible assets (9,248,913) (441,045) Purchases of tangible assets (245,948) (16,694) Net cash outflow for capital expenditure (10,353,360) (944,849) Acquisitions Purchase of subsidiary undertakings - (1,233,435) Payment of deferred consideration (128,399) - Net cash acquired with subsidiary undertakings - 2,213,664 Net cash inflow from acquisitions (128,399) 980,229 Financing Issue of shares 4,181,941 3,309,514 Warrant buy-back - (1,333,333) Receipts from borrowings 6,875,000 9,960,000 Repayment of borrowings (3,763,859) (6,393,312) Capital element of hire purchase contracts (26,031) (25,965) Net cash inflow from financing 7,267,051 5,516,904 (Decrease)/increase in cash in the year 4 (3,303,738) 4,373,015 3. Net cash inflow from operating activities 2005 2004 £ £ Operating profit 2,271,461 704,001 Depreciation of tangible fixed assets 115,229 83,250 Amortisation of intangible fixed assets - 1,750,245 (Increase)/decrease in stocks (729,847) 213,361 (Increase)/decrease in debtors (165,521) (260,649) Increase/(decrease) in creditors 93,882 (377,890) Net cash inflow from operating activities 1,585,204 2,112,318 4. Reconciliation of net cash flow to movement in net debt 2005 2004 £ £ (Decrease)/increase in cash in the year (3,303,738) 4,373,015 Cash inflow from borrowings (3,111,140) (3,566,688) Cash outflow from capital element of hire purchase contracts 26,031 25,965 Cash outflow from loan issue costs paid - 416,125 Change in net debt resulting from cash flows (6,388,847) 1,248,417 Non-cash movements (219,715) 158,955 Net debt at 1 March 2004 (16,002,224) (17,409,596) Net debt at 28 February 2005 (22,610,786) (16,002,224) 5. Basis of preparation The financial information set out in the announcement does not constitute the Group financial statements for the year ended 28 February 2005 or 29 February 2004. The financial information for the year ended 28 February 2004 is derived from the statutory accounts of Alliance Pharma PLC. Those financial statements have been delivered to the Registrar of Companies. The auditors reported on those accounts; their report was unqualified and did not contain a statement under s237(2) or (3) Companies Act 1985. The Group accounts for the year ended 28 February 2005 will be finalised on the basis of the financial information presented by the directors in this preliminary announcement and will be delivered to the Registrar of Companies following the Company's annual general meeting. This information is provided by RNS The company news service from the London Stock Exchange
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