Holding in Company

Microgen PLC
23 January 2001



                  DEALINGS BY SUBSTANTIAL SHAREHOLDERS


1)   NAME OF COMPANY

MICROGEN PLC


2)   NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

EDINBURGH FUND MANAGERS GROUP PLC


3)   Please state whether notification indicates that it is in respect of 
     holding of the Shareholder named in 2 above or in respect of a 
     non-beneficial interest or in the case of an individual holder if it is a
     holding of that person's spouse or children under the age of 18

SHAREHOLDER


4)   Name of the registered holder(s) and, if more than one holder, the 
     number of shares held by each of them.

RBSTB NOMINEES LTD          -  4,007,154

CITY OF EDINBURGH COUNCIL   -    260,914

MINEWORKERS PENSION SCHEME 
 (CHASE GIS) NOMINEES LTD   -    815,300

BRITISH COAL STAFF              
 SUPERANNUATION SCHEME      
 (CHASE GIS) NOMINEES LTD   -    815,300

VIDACOS NOMINEES LTD        -    218,576


5)   Number of shares/amount of stock acquired.

433,200


6)   ( 0.84 %) of issued Class


7)   Number of shares/amount of stock disposed

-


8)   ( - %) of issued Class


9)   Class of security

5p ORDINARY SHARES


10)  Date of transaction

22 JANUARY 2001


11)  Date company informed

22 JANUARY 2001


12)  Total holding following this notification

6,117,244
               
              
13)  Total percentage holding of issued class following this notification

11.94%


14)  Any additional information



15)  Name of contact and telephone number for queries

G.E. LIDDLE
01753 847133


16)  Name and signature of authorised company official responsible for 
     making this notification

     Date of Notification ... 22 JANUARY 2001 ...