Capital Group

AstraZeneca PLC
23 November 2004



Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 23 November 2004 we were informed by The Capital Group Companies, Inc., a
registered investment manager in the U.S., that on 19 November 2004 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 244,411,808
shares (14.78 per cent of the current issued ordinary capital) from the level
notified in July 2004 of 265,952,778 shares (15.89 per cent).  Within the said
holding of 14.78 per cent of the issued ordinary capital of AstraZeneca PLC,
Capital Guardian Trust Company, an affiliate of The Capital Group Companies,
Inc., has decreased its interest in these shares to 93,016,769 shares (5.62 per
cent).





G H R Musker

Company Secretary

23 November 2004



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