Capital Group

AstraZeneca PLC
04 January 2005





Companies Act 1985 Section 198

Disclosure of Interest in Voting Shares in Public Companies



On 31 December 2004 we were informed by The Capital Group Companies, Inc., a
registered investment manager in the U.S., that on 29 December 2004 its interest
in the USD0.25 Ordinary Shares of AstraZeneca PLC had decreased to 229,717,719
shares (13.96 per cent of the current issued ordinary capital) from the
previously notified level of 233,153,407 shares (14.16 per cent).


G H R Musker

Company Secretary

4 January 2005



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