Crestor in Europe

AstraZeneca PLC 03 March 2003 FIRST EUROPEAN LAUNCH FOR CRESTOR(R) IN THE NETHERLANDS AstraZeneca announced today it has launched CRESTOR(R) (rosuvastatin) 10-40 mg for the management of primary hypercholesterolaemia and mixed dyslipidaemia in the Netherlands, the first European market to launch CRESTOR. Dr Gunnar Olsson, Head of the Cardiovascular Therapy Area at AstraZeneca, said: 'An estimated 1.6 million people in the Netherlands have elevated cholesterol levels, putting them at risk of cardiovascular disease. With the efficacy we've seen in clinical studies, CRESTOR has the potential to make a real difference to these patients' lives.' The company plans to launch in the remaining EU markets over the coming months, following the conclusion of the Mutual Recognition Procedure (MRP) and the local Marketing Authorisations and subsequent pricing and reimbursement discussions. The Netherlands acted as the reference member state for the MRP. The Dutch statin market is valued at 240 million Euros ($220 million), and is growing at 15 per cent a year. The global statin market is currently worth approximately US $19 billion annually and is also growing at about 15 per cent a year. The clinical development programme for CRESTOR now involves over 16,000 patients and includes a number of head-to-head comparative studies. In multiple clinical studies, CRESTOR has been shown to be more effective in lowering LDL-cholesterol (LDL-C or 'bad cholesterol') than currently prescribed statins. CRESTOR 10mg gets significantly more patients to their European LDL-C goal than atorvastatin 10mg (82% v 51% respectively), simvastatin 20mg (80% v 48%) and pravastatin 20mg (80% v 16%). In addition to the dramatic reductions seen in LDL-C, CRESTOR produces a significant increase in HDL-C ('good cholesterol'), as well as reducing total cholesterol and triglycerides. CRESTOR is a trade mark of the AstraZeneca group of companies. Media Enquiries: Emily Denney, Tel: +44 (0) 207 304 5034 Steve Brown, Tel: +44 (0) 207 304 5033 Investor Relations: Mina Blair Robinson, Tel: +44 (0) 207 304 5084 Jonathan Hunt, Tel: +44 (0) 207 304 5087 -Ends- This information is provided by RNS The company news service from the London Stock Exchange

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AstraZeneca (AZN)
UK 100

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