Crestor MRP Completion

AstraZeneca PLC 10 March 2003 SUCCESSFUL OUTCOME OF THE MUTUAL RECOGNITION PROCEDURE FOR CRESTOR(R) IN EUROPE AstraZeneca announced today that it has successfully completed the Mutual Recognition Procedure (MRP) in Europe for CRESTOR(R) (rosuvastatin) 10-40 mg for the management of primary hypercholesterolaemia and mixed dyslipidaemia. The Netherlands acted as the reference member state for the MR procedure, and CRESTOR has been launched in that market. National marketing authorisations in an additional 13 countries will be issued in the coming months. Germany, Spain and Norway have been withdrawn from the MR process, and discussions will be held with their agencies to progress further regulatory options. The global statin market is estimated to be worth approximately $19 billion and growing at a rate of around 15 per cent annually. The clinical development programme for CRESTOR now involves over 16,000 patients and includes a number of head-to-head comparative studies. In multiple clinical studies, CRESTOR has been shown to be more effective in lowering LDL-cholesterol (LDL-C or 'bad cholesterol') than currently prescribed statins. CRESTOR 10mg gets significantly more patients to their European LDL-C goal than atorvastatin 10mg (82% v 51% respectively), simvastatin 20mg (80% v 48%) and pravastatin 20mg (80% v 16%). In addition to the dramatic reductions seen in LDL-C, CRESTOR produces a significant increase in HDL-C ('good cholesterol'), as well as reducing total cholesterol and triglycerides. CRESTOR has been approved in Singapore and in Canada, where it was recently launched. It is awaiting approval in the USA, Japan and in other markets. Cardiovascular disease is the leading cause of death worldwide, responsible for up to 17 million deaths per year. CRESTOR, a member of the statin class, is a once daily treatment for dyslipidaemia, a key risk factor in the development of cardiovascular disease, providing important benefits for both patients and health care professionals. CRESTOR is a Trade Mark of the AstraZeneca group of companies. 10 March 2003 Media Enquiries: Emily Denney, Tel: +44 (0) 207 304 5034 Steve Brown, Tel: +44 (0) 207 304 5033 Investor Relations: Mina Blair Robinson, Tel: +44 (0) 207 304 5084 Jonathan Hunt, Tel: +44 (0) 207 304 5087 Notes to Editors: • European MR countries include: Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, the Netherlands, Portugal, Spain, Sweden, the United Kingdom, Iceland and Norway -Ends- This information is provided by RNS The company news service from the London Stock Exchange

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