Director/PDMR Shareholding

AstraZeneca PLC
02 April 2007

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R

We hereby inform you that on 30 March 2007 the following individuals, who are
all persons discharging managerial responsibilities, were granted options under
the AstraZeneca Share Option Plan over the Company's USD0.25 Ordinary Shares or,
in the case of A Zook, over the Company's American Depositary Shares (ADSs).
One ADS equals one Ordinary Share

                       Number of shares over which    Exercise price   Period when exercisable
Name of individual     option is granted              per share

B Angelici             32,887                         2744p                30.3.10-29.3.17

A P Bloxham            18,122                         2744p                30.3.10-29.3.17

J Lundberg             22,659                         2744p                30.3.10-29.3.17

M Nicklasson           29,268                         2744p                30.3.10-29.3.17

D Smith                21,865                         2744p                30.3.10-29.3.17

A Zook                 54,423                         US$53.80             30.3.10-29.3.17

The options will become exercisable on 30 March 2010 subject to certain
performance conditions.  The conditions, which will not be subject to any
retesting, are that the earnings per share of the Company must increase by the
increase in the UK Retail Prices Index plus 5% per annum on average over three
years, and that no significant unforeseen event has taken place which, in the
reasonable opinion of the Remuneration Committee, has resulted in major
reputational damage to AstraZeneca, and the circumstances of which are
exceptional enough to justify the option not vesting and becoming exercisable.
Failure to satisfy either or both of these conditions will result in the lapse
of the option in its entirety.

G H R Musker
Company Secretary
2 April 2007


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