Director/PDMR Shareholding

AstraZeneca PLC
02 April 2007

Dealing by Directors
Companies Act 1985 Sections 324/329

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R

We hereby inform you that on 30 March 2007 the following Directors of
AstraZeneca PLC were each granted an award under the terms of the AstraZeneca
Performance Share Plan over the Company's USD0.25 Ordinary Shares.


                      Target number of   Award price                    Total interest in  Percentage of
                      shares awarded     per share   Normal vesting     shares after this  shares in issue
                                                     date               award
                                                     
Name of Director


D R Brennan           107,051            2744p       30 March 2007      See below          See below

J R Symonds           50,291             2744p       30 March 2007      165,212            0.010%

J S Patterson         36,785             2744p       30 March 2007      131,287            0.009%

The AstraZeneca Performance Share Plan was approved by shareholders at the
Company's AGM in 2005.  Awards made under the Plan may not generally vest before
the third anniversary of the relevant date of grant nor unless the specified
performance target(s) have been met at the end of the three year period which,
for this award, is 1 January 2007 to 31 December 2009.

The performance target that applies to this award is the Company's Total
Shareholder Return ('TSR') compared to the TSR of a selected peer group of 12
other pharmaceutical companies.  The actual number of shares to which a
participant may become unconditionally entitled will depend on the extent to
which the performance target(s) have been met.  A summary of the Plan, including
a more detailed explanation of the performance target(s), can be found in the
AstraZeneca Annual Report and Form 20-F Information 2006 which is available on
the Company's website www.astrazeneca.com.

Mr Brennan has interests in the Company's Ordinary Shares and American
Depositary Shares (ADSs).  One ADS equals one Ordinary Share.  In total, Mr
Brennan now has an interest in 217,618 Ordinary Shares and 140,803 ADSs which
together represent approximately 0.024% of the number of shares currently in
issue.

G H R Musker
Company Secretary
2 April 2007




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