Director/PDMR Shareholding

AstraZeneca PLC
25 August 2005

Dealing by Directors
Companies Act 1985 Sections 324/329


Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 24 August 2005 Dr John Buchanan, a Director of the
Company, purchased 2,000 AstraZeneca PLC USD0.25 Ordinary Shares at a price of
2532 pence per share.

Following this purchase, Dr Buchanan's total holding in the Company is 2,500
shares, which represents approximately 0.0002% of the issued ordinary capital of
the Company.



G H R Musker
Company Secretary
25 August 2005


                      This information is provided by RNS
            The company news service from the London Stock Exchange