Director/PDMR Shareholding

AstraZeneca PLC
25 August 2006

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 24 August 2006, Barrie Thorpe, a person discharging
managerial responsibilities, exercised options over 30,802 AstraZeneca PLC
USD0.25 Ordinary Shares as follows:

- option over 1,795 shares at an option price of 2674 pence per share

- option over 29,007 shares at an option price of 2231 pence per share


The options were granted to Mr Thorpe under the Company's 1994 Executive Share
Option Scheme and the AstraZeneca Share Option Plan.


We also inform you that on 24 August 2006, Mr Thorpe sold the 30,802 shares
acquired from the exercise at an average price of 3322 pence per share.




G H R Musker
Company Secretary
25 August 2006


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