Director/PDMR Shareholding

AstraZeneca PLC
25 April 2007


Transaction by Person Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R


We hereby inform you that on 24 April 2007, Martin Nicklasson, Executive
Vice-President, Global Marketing, a person discharging managerial
responsibilities, exercised options over 52,571 AstraZeneca PLC USD0.25 Ordinary
Shares as follows:


- option over 15,151 shares at an option price of 2508 pence per share


- option over 28,209 shares at an option price of 2529 pence per share


- option over 9,211 shares at an option price of 2714 pence per share


The options were granted to Mr Nicklasson under the AstraZeneca Share Option
Plan.


We also inform you that on 24 April 2007, Mr Nicklasson sold the 52,571 shares
acquired from the exercise at a price of 2781 pence per share.


G H R Musker

Company Secretary

25 April 2007


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