Director/PDMR Shareholding

AstraZeneca PLC
22 September 2006

Dealing by Directors
Companies Act 1985 Sections 324/329

We hereby inform you that on 21 September 2006 Mr John Varley, a Director of the
Company, purchased 500 AstraZeneca PLC USD0.25 Ordinary Shares at a price of
3346 pence per share.

This represents Mr Varley's total interest, which is approximately 0.00003% of
the issued ordinary capital of the Company.

G H R Musker
Company Secretary
22 September 2006


                      This information is provided by RNS
            The company news service from the London Stock Exchange