Director/PDMR Shareholding

AstraZeneca PLC
30 July 2007


Transaction by Person Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R


We hereby inform you that on 27 July 2007, Jon Symonds, a Director of the
Company, exercised options over 165,195 AstraZeneca PLC USD0.25 Ordinary Shares
as follows:

- option over 30,656 shares at an option price of 2055 pence per share

- option over 13,136 shares at an option price of 2398 pence per share

- option over 29,342 shares at an option price of 2505 pence per share

- option over 48,012 shares at an option price of 2231 pence per share

- option over 44,049 shares at an option price of 2529 pence per share


The options were granted to Mr Symonds under the Company's 1994 Executive Share
Option Plan or the AstraZeneca Share Option Plan between the date of his
appointment as a Director in October 1997 and March 2004.  As a consequence of
Mr Symonds' resignation as a Director and employee of the Company on 31 July
2007, these options will expire if not exercised before then.

We also inform you that on 27 July 2007, Mr Symonds sold the 165,195 shares
acquired from the exercise at a price of 2577 pence per share.

As a result of these transactions, at the date of this notice Mr Symonds holds
options over 86,749 Ordinary Shares of AstraZeneca PLC and has an interest in
the Ordinary Shares of the Company of 165,212 shares, which represents
approximately 0.01% of the issued ordinary capital of the Company.  Upon his
leaving the Company on 31 July 2007 the options over 86,749 Ordinary Shares will
lapse and his interest in the Ordinary Shares of the Company will reduce to
11,527 shares.


G H R Musker
Company Secretary
30 July 2007


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