Director/PDMR Shareholding

AstraZeneca PLC
27 February 2008



Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4



We hereby inform you that on 25 February 2008, the following individuals, who
are all persons discharging managerial responsibilities, acquired an interest in
the USD0.25 Ordinary Shares of AstraZeneca PLC or, in the case of D Mott, L
Tetrault and A Zook, over the Company's American Depositary Shares (ADSs).  One
ADS equals one Ordinary Share.  The interest arises as a result of the
previously disclosed arrangements relating to the payment of annual bonuses for
2007 whereby each individual is required to defer a portion of the bonus earned
into shares for a period of three years.  The shares are awarded under the terms
of the AstraZeneca Deferred Bonus Plan.  The individuals will become
beneficially entitled to these shares on 25 February 2011.


                                Number of shares    Award price per
Name                            allocated           share


B Angelici                      2,369               1999p


J Lundberg                      2,343               1999p


D Mott                          5,390               US$39.47




D Smith                         2,026               1999p




L Tetrault                      1,198               US$39.47


A Zook                          2,546               US$39.47









G H R Musker
Company Secretary

27 February 2008


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