Director/PDMR Shareholding

AstraZeneca PLC
26 March 2008

Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DTR 3.1.4R


We hereby inform you that the interest of Lynn Tetrault, a person discharging
managerial responsibility, in the shares of AstraZeneca PLC has changed as
detailed below.  Mrs Tetrault has interests in the American Depositary Shares
(ADSs) of AstraZeneca PLC.  One ADS equals one Ordinary Share.


On 24 March 2008, Mrs Tetrault became unconditionally entitled to a final award
of 4,478 ADSs on the partial vesting of an original target award of 4,665 ADSs,
which were awarded to her in March 2005 under the terms of the AstraZeneca US
Executive Performance Share Plan.  Mrs Tetrault has ceased to have an interest
in the 187 ADSs of the original target award that did not vest.  After certain
mandatory tax deductions, Mrs Tetrault has received 2,580 ADSs into a personal
brokerage account.


The closing price of AstraZeneca ADSs on 20 March 2008 was US$37.63.




G H R Musker
Company Secretary
26 March 2008


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