Director/PDMR Shareholding

AstraZeneca PLC
26 March 2008


Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DTR 3.1.4R


We hereby inform you that the interest of Anthony Zook, a person discharging
managerial responsibility, in the shares of AstraZeneca PLC has changed as
detailed below.  Mr Zook has interests in the American Depositary Shares (ADSs)
of AstraZeneca PLC.  One ADS equals one Ordinary Share.


On 24 March 2008, Mr Zook became unconditionally entitled to a final award of
7,717 ADSs on the partial vesting of an original target award of 8,039 ADSs,
which were awarded to him in March 2005 under the terms of the AstraZeneca US
Executive Performance Share Plan.  Mr Zook has ceased to have an interest in the
322 ADSs of the original target award that did not vest.  After certain
mandatory tax deductions, Mr Zook has received 5,217 ADSs into a personal
brokerage account.


The closing price of AstraZeneca ADSs on 20 March 2008 was US$37.63.


G H R Musker

Company Secretary

26 March 2008


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