Director/PDMR Shareholding

AstraZeneca PLC 31 March 2008 Transaction by Persons Discharging Managerial Responsibilities Disclosure Rules DTR 3.1.4R We hereby inform you that on 28 March 2008 the following individuals, who are all persons discharging managerial responsibilities, were granted options under the AstraZeneca Share Option Plan over the Company's USD0.25 Ordinary Shares or, in the case of D Mott, L Tetrault and A Zook, over the Company's American Depositary Shares (ADSs). One ADS equals one Ordinary Share Number of shares over which Exercise price per Period when exercisable Name of individual option is granted share B Angelici 49,628 1882p 28.3.11-27.3.18 J Lundberg 48,445 1882p 28.3.11-27.3.18 D Mott 121,478 US$37.76 28.3.11-27.3.18 D Smith 36,131 1882p 28.3.11-27.3.18 L Tetrault 67,302 US$37.76 28.3.11-27.3.18 A Zook 96,971 US$37.76 28.3.11-27.3.18 The options will become exercisable on 28 March 2011 subject to certain performance conditions. The conditions, which will not be subject to any retesting, are that the earnings per share of the Company must increase by the increase in the UK Retail Prices Index plus 5% per annum on average over three years, and that no significant unforeseen event has taken place which, in the reasonable opinion of the Remuneration Committee, has resulted in major reputational damage to AstraZeneca, and the circumstances of which are exceptional enough to justify the option not vesting and becoming exercisable. Failure to satisfy either or both of these conditions will result in the lapse of the option in its entirety. G H R Musker Company Secretary 31 March 2008 This information is provided by RNS The company news service from the London Stock Exchange

Companies

AstraZeneca (AZN)
UK 100

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