Director/PDMR Shareholding

RNS Number : 2703V

AstraZeneca PLC

29 October 2010

Transactions by Persons Discharging Managerial Responsibilities

Disclosure Rule DTR 3.1.4

We hereby inform you that on 29 October 2010 the following Directors of the Company notified us that, on 29 October 2010, they purchased AstraZeneca PLC Ordinary Shares of $0.25 each.

Name of Director	Number of shares purchased	Purchase price	Number of shares held following purchase	Percentage of shares in issue
Louis Schweitzer	2,460	3137p	9,115	0.0006
Jane Henney	252	3137p	1,314	0.00009
Rudy Markham	249	3137p	1,940	0.0001
Nancy Rothwell	252	3137p	1,314	0.00009