Transaction by Person Discharging Managerial Responsibilities
Disclosure Rules DTR 3.1.4R
We hereby inform you that the interest of Simon Lowth, a Director of the Company, in the ordinary shares of AstraZeneca PLC has changed as detailed below.
On 26 April 2013, Mr Lowth exercised an option over 65,131 AstraZeneca ordinary shares at an option price of 2280 pence per share. Immediately following the exercise, Mr Lowth sold 54,561 of the 65,131 shares so acquired at a price of 3316 pence per share to cover the cost of exercise and associated taxes. He retained the balance of 10,570 shares.
On 29 April 2013, Mr Lowth sold 8,690 AstraZeneca ordinary shares at a price of 3328 pence per share for reasons of personal financial planning.
As a result of these transactions, Mr Lowth has an interest in 299,931 shares, which represent approximately 0.02% of the Company's issued ordinary capital.
A C N Kemp
Company Secretary
29 April 2013