Director/PDMR Shareholding

AstraZeneca PLC
01 March 2006

Dealing by Directors

Companies Act 1985 Sections 324/329



Transaction by Persons Discharging Managerial Responsibilities

Disclosure Rules DR 3.1.2R



We hereby inform you that the interest of David R. Brennan, a Director of the
Company, in the shares of AstraZeneca PLC has changed as detailed below.  Mr
Brennan has interests in both the Ordinary Shares and the American Depositary
Shares (ADSs) of AstraZeneca PLC.  One ADS equals one Ordinary Share.



On 24 February 2006, Mr Brennan received an allocation of 6,352 Ordinary Shares
under the previously disclosed arrangements relating to his annual bonus for
2005 whereby he is required to defer a portion of the bonus earned into shares
for a period of three years.  The shares were allocated at a price of 2639 pence
per share.  Mr Brennan will become beneficially entitled to these shares on 24
February 2009.



On 24 February 2006, Mr Brennan received a scheduled distribution out of the
AstraZeneca US Executive Deferral Plan, a unitised stock fund established in
2000, in which Mr Brennan, in common with other participating US executives, is
deemed to have a notional interest in ADSs calculated by reference to the fund
value and the closing price of AstraZeneca ADSs.  Following this scheduled
distribution on 24 February 2006, Mr Brennan had a notional interest in 70,387
ADSs within the AstraZeneca US Executive Deferral Plan by reference to the
closing price on 24 February 2006 of US$46.14.



On 27 February 2006, Mr Brennan purchased, on his own account, additional ADSs
to be held within the AstraZeneca US Executive Deferral Plan bringing his
notional interest in ADSs held within the AstraZeneca US Executive Deferral Plan
as at 27 February 2006 to 75,955 ADSs based on that day's closing price of
US$46.58.



In total, Mr Brennan now has an interest in 6,352 Ordinary Shares and 172,088
AstraZeneca ADSs, including the notional interest in ADSs in the AstraZeneca US
Executive Deferral Plan referred to above.





G H R Musker
Company Secretary
1 March 2006




                      This information is provided by RNS
            The company news service from the London Stock Exchange