Director/PDMR Shareholding

AstraZeneca PLC
19 September 2007


Dealing by Directors
Companies Act 1985 Sections 324/329


Transaction by Persons Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 17 September 2007 Mr Bo Angelin, a Director of the
Company, notified us that, on 14 September 2007, he purchased 500 AstraZeneca
PLC USD0.25 Ordinary Shares at a price of SEK320 per share.


This represents Mr Angelin's total interest, which is approximately 0.00003% of
the issued ordinary capital of the Company.




G H R Musker
Company Secretary
19 September 2007



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