Director/PDMR Shareholding

AstraZeneca PLC
09 August 2006



Dealing by Director
Companies Act 1985 Sections 324/329



Transaction by Person Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R



We hereby inform you that on 8 August 2006, David R Brennan, a Director of the
Company, exercised an option over 85,397 AstraZeneca PLC American Depositary
Shares (ADSs) at an option price of $35.16 per ADS.  One ADS equals one USD0.25
Ordinary Share.  The option was granted to Mr Brennan under the AstraZeneca
Share Option Plan.



We also inform you that on 8 August 2006, Mr Brennan sold the 85,397 ADSs
acquired from the exercise at a price of $61.07 per ADS.



Mr Brennan intends to use the sale proceeds, less the cost of exercising the
option and any applicable taxes, in connection with the purchase of a home in
the UK.



As a result of the exercise and sale referred to above, Mr Brennan holds options
over 355,246 ADSs and 110,641 Ordinary Shares of AstraZeneca PLC and has an
interest in 167,453 ADSs and 98,553 Ordinary Shares of the Company, which
represents approximately 0.017% of its issued ordinary capital.







G H R Musker
Company Secretary
9 August 2006


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