Director/PDMR Shareholding

AstraZeneca PLC
19 December 2006

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rules DR 3.1.2R


We hereby inform you that on 19 December 2006, Bruno Angelici, Executive
Vice-President, Europe, Japan, Asia Pacific and rest of world, a person
discharging managerial responsibilities, exercised an option over 5,753
AstraZeneca PLC USD0.25 Ordinary Shares at an option price of 1740 pence per
share.


The option was granted to Mr Angelici in April 1997 under the Company's 1994
Executive Share Option Scheme.


We also inform you that on 19 December 2006, Mr Angelici sold the 5,753 shares
acquired from the exercise at an average price of 2842 pence per share.


G H R Musker
Company Secretary
19 December 2006


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