Director Shareholding

AstraZeneca PLC
15 November 2000


DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTION 324/329

WE HEREBY CONFIRM THAT ON 13 NOVEMBER 2000 THE FOLLOWING DIRECTORS OF
ASTRAZENECA PLC ACQUIRED AN INTEREST IN THE USD0.25 ORDINARY SHARES OF THE
COMPANY.  THESE INTERESTS, WHICH ARE REGISTERED IN THE NAMES OF THE DIRECTORS
CONCERNED, ARISE AS A RESULT OF AN ALLOCATION OF ASTRAZENECA SHARES TO
PARTICIPANTS IN THE COMPANY'S SAVINGS RELATED SHARE OPTION SCHEME. IMMEDIATELY
FOLLOWING THE ACQUISITION SOME OF THE SHARES WERE SOLD BY THE COMPANY ON
BEHALF OF THE DIRECTORS IN ORDER TO MEET AN IMMEDIATE INCOME TAX LIABILITY
ARISING ON THE ALLOCATION OF THE SHARES.

NAME OF DIRECTOR  NUMBER OF     NUMBER OF    TOTAL       PERCENTAGE
                  SHARES        SHARES       INTEREST    OF ISSUED 
                  ACQUIRED      SOLD                     SHARES       
                            
T F W McKILLOP    7             3            72,557      0.004

J R SYMONDS       5             3            13,316      0.001
                            

THE PRICE AT WHICH THE SHARES WERE ACQUIRED AND SOLD WAS 3375P.

G H R MUSKER
COMPANY SECRETARY
15 NOVEMBER 2000