Director Shareholding

AstraZeneca PLC
17 November 2000


DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTION 324/329

WE HEREBY CONFIRM THAT ON 16 NOVEMBER 2000 THE FOLLOWING DIRECTORS OF
ASTRAZENECA PLC ACQUIRED AN INTEREST IN THE USD0.25 ORDINARY SHARES OF THE
COMPANY.  THESE INTERESTS, WHICH WILL BE REGISTERED IN THE NAME OF ASTRAZENECA
SHARE TRUST LIMITED, ARISE AS A RESULT OF A REVOCABLE ALLOCATION OF
ASTRAZENECA SHARES TO PARTICIPANTS IN THE COMPANY'S EXECUTIVE SHARE OPTION
SCHEMES.  THE SHARES WILL NOT BECOME BENEFICIALLY OWNED BY THE DIRECTORS UNTIL
13 NOVEMBER 2003.  IF A DIRECTOR CEASES TO BE EMPLOYED BY THE COMPANY BEFORE
THIS DATE THE ALLOCATION OF SHARES MAY BE REVOKED.

NAME OF DIRECTOR    NUMBER OF SHARES    TOTAL INTEREST    PERCENTAGE OF       
                                                            ISSUED SHARES

T F W McKILLOP      1,378               73,935            0.004
H L MOGREN            684               65,706            0.004
A B T STAVLING        417                8,578            0.001
J R SYMONDS           726               14,042            0.001
C E WILHELMSSON       458               27,123            0.002


THE PRICE OF ORDINARY SHARES OF ASTRAZENECA PLC AT CLOSE OF BUSINESS ON 16
NOVEMBER 2000 WAS 3235P.

G H R MUSKER
COMPANY SECRETARY