Director Shareholding

AstraZeneca PLC
21 February 2002


DEALING BY DIRECTORS
COMPANIES ACT 1985 SECTION 324/329

WE HEREBY INFORM YOU THAT, ON 19 FEBRUARY 2002, WE WERE NOTIFIED BY MR A B T
STAVLING, A DIRECTOR OF THE COMPANY, THAT, ON 15 FEBRUARY 2002, HE SOLD OPTIONS
OVER ASTRAZENECA PLC ORDINARY SHARES OF USD0.25 EACH AS FOLLOWS:-

NUMBER OF OPTIONS SOLD         SALE PRICE PER OPTION           DATE OF SALE

2,717                          318.18SEK                       15.02.02

3,267                          306.14SEK                       15.02.02


THESE OPTIONS WERE ORIGINALLY GRANTED TO MR STAVLING OVER SHARES IN ASTRA AB
UNDER THE ASTRA SHAREHOLDER VALUE INCENTIVE PLAN AND WERE CONVERTED INTO OPTIONS
OVER ORDINARY SHARES IN ASTRAZENECA PLC IN APRIL 1999.  DETAILS OF THE
UNDERLYING ASTRAZENECA SHARES OVER WHICH THE OPTIONS WERE HELD ARE AS FOLLOWS:-

NUMBER OF ASTRAZENECA     EFFECTIVE OPTION       CLOSING PRICE OF ASTRAZENECA
SHARES OVER WHICH         PRICE PER SHARE        SHARES ON DATE OPTIONS 
OPTIONS WERE HELD                                WERE SOLD

3,655                      298.28SEK              533SEK

4,395                      316.13SEK              533SEK


FOLLOWING THESE TRANSACTIONS, MR STAVLING HOLDS OPTIONS OVER 92,340 ORDINARY
SHARES OF ASTRAZENECA PLC.

G H R MUSKER
COMPANY SECRETARY

21 FEBRUARY 2002


                      This information is provided by RNS
            The company news service from the London Stock Exchange